Titre du document / Document title

Anti-allergic and anti-asthmatic activity of helioscopinin-A, a polyphenol compound, isolated from Euphorbia helioscopia

Auteur(s) / Author(s)

PARK Kwan Ha ⁽¹⁾ ; KOH Dongsoo ⁽²⁾ ; LEE Seungho ⁽³⁾ ; JUNG Illmin ⁽⁴⁾ ; KYUNG HYUN KIM ⁽⁵⁾ ; LEE Chul-Hoon ⁽⁶⁾ ; KIM Kye-Hoon ⁽⁷⁾ ; LIM Yoongho ⁽⁸⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Marine Biomedical Sciences, Kunsan National University, Chonbuk 573-702, COREE, REPUBLIQUE DE
⁽²⁾ Department of Applied Chemistry, Dongduk Women's University, Seoul 136-716, COREE, REPUBLIQUE DE
⁽³⁾ College of Pharmacy, Yeungnam University, Kyongpook 712-749, COREE, REPUBLIQUE DE
⁽⁴⁾ Department of Crop Science, Konkuk University, Seoul 143-701, COREE, REPUBLIQUE DE
⁽⁵⁾ Graduate School of Biotechnology, Korea University, Seoul 136-701, COREE, REPUBLIQUE DE
⁽⁶⁾ Department of Medical Genetics and Institute of Biomedical Science, College of Medicine, Hanyang University, Seoul 133-791, COREE, REPUBLIQUE DE
⁽⁷⁾ Department of Environmental Horticulture, The University of Seoul, Seoul 130-743, COREE, REPUBLIQUE DE
⁽⁸⁾ Department of Applied Biology and Chemistry, Konkuk University, Seoul 143-701, COREE, REPUBLIQUE DE

Résumé / Abstract

During the course of searching for anti-allergic substances from unexplored plant sources, an inhibitor of leukotriene D₄-induced tracheal contraction was isolated from Euphorbia helioscopia. This isolated polyphenol compound, known as helioscopinin-A, showed a certain inhibitory activity on capillary permeability in passive cutaneous anaphylaxis responses of rats and also on antigen-induced bronchial constriction in an experimental asthma model of guinea pigs. The compound at a high concentration weakly inhibited histamine release from isolated mast cells of rats. It is suggested that this compound is an anti-allergic and anti-asthmatic which exerts its activity through antagonism on leukotriene D₄-induced responses. A partial inhibition of allergic mediator release may also be involved.

Revue / Journal Title

Journal of microbiology and biotechnology    ISSN  1017-7825 

Source / Source

2001, vol. 11, n^o1, pp. 138-142 (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

Korean Society for Applied Microbiology, Seoul, COREE, REPUBLIQUE DE  (1991) (Revue)

Mots-clés anglais / English Keywords

Polyphenol

;

Plant origin

;

Antiallergic

;

Chemical structure

;

Antiasthma agent

;

Euphorbiaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Mots-clés français / French Keywords

Polyphénol

;

Origine végétale

;

Antiallergique

;

Structure chimique

;

Antiasthmatique

;

Euphorbia helioscopia

;

Hélioscopinine A

;

Euphorbiaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Mots-clés espagnols / Spanish Keywords

Polifenol

;

Origen vegetal

;

Antialérgico

;

Estructura química

;

Agente antiasma

;

Euphorbiaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Localisation / Location

INIST-CNRS, Cote INIST : 26482, 35400009462814.0230