Titre du document / Document title

Transfer of carisoprodol to breast milk

Auteur(s) / Author(s)

NORDENG Hedvig ⁽¹⁾ ; ZAHLSEN Kolbjørn ⁽²⁾ ; SPIGSET Olav ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Pharmacotherapeutics, University of Oslo, Oslo, NORVEGE
⁽²⁾ Department of Clinical Pharmacology, Regional and University Hospital, Trondheim, NORVEGE

Résumé / Abstract

There is no published information on the transfer of the centrally acting muscle relaxant carisoprodol and its active metabolite meprobamate into breast milk. The objective of this study was to quantify the excretion of carisoprodol and meprobamate in human milk and estimate the dose received by breast-fed infants. The concentrations of carisoprodol and meprobamate were measured in breast milk on 4 consecutive days at steady-state conditions in one woman using carisoprodol 2100 mg/d. The average milk concentrations were 0.9 μg/mL for carisoprodol and 11.6 μg/mL for meprobamate. Based on the milk concentrations measured, the absolute dose ingested by an exclusively breast-fed infant could be estimated at 1.9 mg/kg per day, and the relative dose would be 4.1% of the weight-adjusted maternal dose. No adverse effects were observed in the infant, but the infant was partly fed with formula because of insufficient maternal milk production. Thus, the authors consider that at least during prolonged use, lactation is generally inadvisable until more clinical data are available.

Revue / Journal Title

Therapeutic drug monitoring   ISSN 0163-4356   CODEN TDMODV 

Source / Source

2001, vol. 23, n^o3, pp. 298-300 (5 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS  (1979) (Revue)

Mots-clés anglais / English Keywords

Carisoprodol ; Meprobamate ; Metabolite ; Muscle relaxant ; Pharmacokinetics ; Milk transfer ; Breast milk ; Breast feeding ; Human ; Female ; Case study ; Organic carbamate ;

Mots-clés français / French Keywords

Carisoprodol ; Méprobamate ; Métabolite ; Myorésolutif ; Pharmacocinétique ; Passage lait ; Lait maternel ; Allaitement ; Homme ; Femelle ; Etude cas ; Carbamate organique ;

Mots-clés espagnols / Spanish Keywords

Carisoprodol ; Meprobamato ; Metabolito ; Relajante muscular ; Farmacocinética ; Paso leche ; Leche materna ; Lactancia ; Hombre ; Hembra ; Estudio caso ; Carbamato orgánico ;

Localisation / Location

INIST-CNRS, Cote INIST : 18087, 35400009830085.0200