Titre du document / Document title

Efficacy and safety of sildenafil citrate for the treatment of erectile dysfunction in men with cardiovascular disease

Auteur(s) / Author(s)

OLSSON A. M. ⁽¹⁾ ; PERSSON C.-A. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Urology, University Hospital, Lund, SUEDE
⁽²⁾ Pfizer Sweden, SUEDE

Résumé / Abstract

Men with cardiovascular disease (CVD) are more likely to have erectile dysfunction (ED) than the general population, as both conditions share risk factors and some drugs used to treat CVD may induce ED as a side-effect. This study was undertaken to assess the efficacy and safety of sildenafil citrate for the treatment of ED in men with CVD who were receiving treatment with β-blockers and/or angiotensin-converting enzyme inhibitors and/or calcium-channel blockers, but not nitrates. Treatment with sildenafil was associated with significant increases in the mean end-of-treatment scores for the questions from the International Index of Erectile Function that assess the ability to achieve and maintain erections (p=0.0001). Furthermore, 71% of patients taking sildenafil reported improved erections compared with 24% taking placebo (p=0.0001). This study also showed that sildenafil was well tolerated in patients with CVD and ED. Besides flushing, no treatment-related cardiovascular adverse events were noted for sildenafil.

Revue / Journal Title

International journal of clinical practice   ISSN 1368-5031 

Source / Source

2001, vol. 55, n^o3, pp. 171-176 (22 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1997) (Revue)

Mots-clés anglais / English Keywords

Impotence ; Concomitant disease ; Hypertension ; Infarct ; Myocardium ; Double blind study ; Sildenafil ; Chemotherapy ; Toxicity ; Treatment efficiency ; Adult ; Male ; Human ; Male genital diseases ; Erection disorders ; Cardiovascular disease ; Coronary heart disease ; Myocardial disease ; Treatment ;

Mots-clés français / French Keywords

Impuissance ; Association morbide ; Hypertension artérielle ; Infarctus ; Myocarde ; Etude double insu ; Sildénafil ; Chimiothérapie ; Toxicité ; Efficacité traitement ; Adulte ; Mâle ; Homme ; Appareil génital mâle pathologie ; Erection pathologie ; Appareil circulatoire pathologie ; Cardiopathie coronaire ; Myocarde pathologie ; Traitement ;

Mots-clés espagnols / Spanish Keywords

Impotencia ; Asociación morbosa ; Hipertensión arterial ; Infarto ; Miocardio ; Estudio doble ciego ; Sildenafilo ; Quimioterapia ; Toxicidad ; Eficacia tratamiento ; Adulto ; Macho ; Hombre ; Aparato genital macho patología ; Erección patología ; Aparato circulatorio patología ; Cardiopatía coronaria ; Miocardio patología ; Tratamiento ;

Localisation / Location

INIST-CNRS, Cote INIST : 15561, 35400009530123.0050