Titre du document / Document title

Serum human chorionic gonadotropin levels are correlated with body mass index rather than route of administration in women undergoing in vitro fertilization-embryo transfer using human menopausal gonadotropin and intracytoplasmic sperm injection

Auteur(s) / Author(s)

ELKIND-HIRSCH Karen E. ⁽¹⁾ ; BELLO Sandra ⁽¹⁾ ; ESPARCIA Lori ⁽¹⁾ ; PHILLIPS Kathy ⁽¹⁾ ; SHEIKO Alex ⁽¹⁾ ; MCNICHOL Milton ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Center for Reproduction at Gramercy, MacGregor Medical Association, Houston, Texas, ETATS-UNIS

Résumé / Abstract

Objective: To compare subcutaneous (SC) and intramuscular (IM) hCG administration and their association with body mass index (BMI) in women undergoing IVF-ET using hMG and ICSI. Design: Prospective, randomized controlled trial. Setting: Private infertility clinic Patient(s): Twenty-one ovulatory women, 29-39 years, were enrolled. Treatment of one patient who failed to respond to hMG was canceled. Intervention(s): A standard IVF-ET treatment plan using an initial dose of 300 U of hMG was followed. Patients were randomly assigned to receive 10,000 IU hCG, either IM in the gluteal region or SC in the lower abdomen. Exactly 12 hours later, serum for hCG determination was obtained. All oocytes were fertilized using ICSI technology. Main Outcome Measure(s): Human chorionic gonadotropin levels 12 hours after injection, BMI, and oocyte maturity. Result(s): No significant differences in hCG levels were found, with mean levels of 225 ± 24 mIU/mL for SC injection versus 213 ± 26 mIU/mL for IM injection. No differences were observed in the percentage of mature oocytes. A significant negative correlation was found between BMI and hCG levels in all patients, regardless of route of administration. Conclusion(s): The highest levels of hCG were measured in women with the lowest BMI. Patients' body size, rather than route of hCG delivery, appears to determine circulating levels of hCG.

Revue / Journal Title

Fertility and sterility   ISSN 0015-0282   CODEN FESTAS 

Source / Source

2001, vol. 75, n^o4, pp. 700-704 (14 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1950) (Revue)

Mots-clés anglais / English Keywords

Human chorionic gonadotrophin ; HMG ; In vitro fertilization embryo transfer ; Oocyte ; Intracytoplasmic sperm injection ; Subcutaneous administration ; Intramuscular administration ; Body mass index ; Oocyte maturation ; Female ; Human ; Gonadotropin ; Placental hormone ; Assisted procreation ; Germinal cell ;

Mots-clés français / French Keywords

HCG ; HMG ; Fécondation in vitro transfert embryon ; Ovocyte ; Injection spermatozoïde intracytoplasmique ; Voie souscutanée ; Voie intramusculaire ; Indice masse corporelle ; Maturation oeuf ; Femelle ; Homme ; Gonadotrophine ; Hormone placentaire ; Procréation assistée ; Cellule germinale ;

Mots-clés espagnols / Spanish Keywords

HCG ; HMG ; Fecundación in vitro transplante embrión ; Ovocito ; Inyección espermatozoide intracitoplásmica ; Vía subcutánea ; Vía intramuscular ; Indice masa corporal ; Maduración huevo ; Hembra ; Hombre ; Gonadotropina ; Hormona placentaria ; Procreación asistida ; Célula germinal ;

Localisation / Location

INIST-CNRS, Cote INIST : 4120, 35400009815284.0110