Titre du document / Document title

Relatively low serum leptin levels in adults born with intra-uterine growth retardation

Auteur(s) / Author(s)

JAQUET D. ⁽¹⁾ ; GABORIAU A. ⁽¹⁾ ; CZERNICHOW P. ⁽¹⁾ ; LEVY-MARCHAL C. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ INSERM Unit 457, Hôpital Robert Debré, Paris, FRANCE

Résumé / Abstract

BACKGROUND: In-utero under-nutrition dramatically alters the development of adipose tissue, during the fetal and the neonatal period. THE AIM OF THE STUDY: To investigate whether adults born with intra-uterine growth retardation (IUGR) show evidence of impaired adipose tissue development and leptin regulation. DESIGN: Serum leptin concentrations were measured in 26 healthy adults born with IUGR and 25 controls aged 24 y who have been studied previously, 3y ago. RESULTS: The IUGR group demonstrated a significant increase of body mass index (BMI) in comparison to controls between 21 and 24y of age (4.8 ± 7.7%, P= 0.004 vs 0.8 ± 6.7%, P= 0.70). Percentage of total body fat mass was significantly higher in IUGR-born subjects than in controls (27.2 ± 7.6 vs 22.0 ± 7.3%, P = 0.02). Fasting insulin was significantly higher in the IUGR group (7.5 ± 3.8 vs 5.3 ± 2.3 μU/ml, P = 0.03). Surprisingly, crude serum leptin concentrations did not significantly differ between the two groups. Moreover, adjusted means of serum leptin levels were significantly lower in IUGR-born subjects than in controls when corrected for body fat mass, gender and fasting insulin (11.3 vs 13.8 ng/ml, P= 0.02). Adults born with IUGR developed an excess of adipose tissue associated with relatively low serum leptin levels suggestive of an altered adipocyte function. Considering the close relationship between adipose tissue and insulin-sensitivity, these observations point to the potential implication of abnormal adipose tissue development in the long-term metabolic consequences associated with in-utero undernutrition.

Revue / Journal Title

International journal of obesity   ISSN 0307-0565   CODEN IJOBDP 

Source / Source

2001, vol. 25, n^o4, pp. 491-495 (29 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing, Basingstoke, ROYAUME-UNI  (1977) (Revue)

Mots-clés anglais / English Keywords

Intrauterine growth retardation ; Case control study ; Malnutrition ; Fetus ; Antecedent ; Leptin ; Hormonal investigation ; Blood plasma ; Insulin ; Body mass index ; Body composition ; Fat mass ; Adult ; Human ; Pregnancy disorders ; Fetal diseases ; Nutrition disorder ; Pancreatic hormone ;

Mots-clés français / French Keywords

Hypotrophie foetale ; Etude cas témoin ; Malnutrition ; Foetus ; Antécédent ; Leptine ; Exploration hormonale ; Plasma sanguin ; Insuline ; Indice masse corporelle ; Composition corporelle ; Masse grasse ; Adulte ; Homme ; Gestation pathologie ; Foetus pathologie ; Trouble nutrition ; Hormone pancréatique ;

Mots-clés espagnols / Spanish Keywords

Hipotrofia fetal ; Estudio caso control ; Malnutrición ; Feto ; Antecedente ; Leptina ; Análisis hormonal ; Plasma sanguíneo ; Insulina ; Indice masa corporal ; Composicíon corporal ; Masa grasa ; Adulto ; Hombre ; Gestación patología ; Feto patología ; Trastorno nutricíon ; Hormona pancreática ;

Localisation / Location

INIST-CNRS, Cote INIST : 18243, 35400009512014.0080