Titre du document / Document title

Conventional and power spectrum analysis of the effects of Zolpidem on Sleep EEG in patients with chronic primary insomnia

Auteur(s) / Author(s)

MONTI Jaime M. ⁽¹⁾ ; ALVARINO Fernando ⁽¹⁾ ; MONTI Daniel ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Pharmacology and Therapeutics, Clinics Hospital, Montevideo, URUGUAY
⁽²⁾ Department of Psychiatry, The University of Utah at Salt Lake City, ETATS-UNIS

Résumé / Abstract

Study Objective: The purpose of this study was 1) to assess the effect of zolpidem or a placebo on sleep in two groups of insomniac patients with a diagnosis of moderate-to-severe chronic primary insomnia and 2) to determine the effect of zolpidem on sleep structure using spectral analysis. Design: A randomized, double-blind, placebo-controlled trial. Setting: Sleep laboratory of the Department of Pharmacology and Therapeutics at the Clinics Hospital. Participants: 12 female outpatients with chronic primary insomnia Interventions: Zolpidem was given at a daily dose of 10 mg for 15 nights. Results: The hypnotic drug reduced sleep latency and waking time after sleep onset, and increased total sleep time and sleep efficiency. Values corresponding to visually scored slow wave sleep (stage 3 and 4) showed no significant changes. All-night spectral analysis of the EEG revealed that power density in NREM sleep was significantly increased in the low frequency band (0.25-1.0 Hz) in the zolpidem group during the first 2-h interval. Conclusions: In agreement with previous findings obtained in patients with chronic primary insomnia, zolpidem significantly improved sleep induction and maintenance. Moreover, zolpidem increased power density in the 0.25-1.0 Hz band during short-term and intermediate-term treatment. Nevertheless, other frequency bands in the delta range showed a relative decrease which was not statistically significant.

Revue / Journal Title

Sleep   ISSN 0161-8105   CODEN SLEED6 

Source / Source

2000, vol. 23, n^o8, pp. 1075-1084 (31 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Academy of Sleep Medicine, Rochester, MN, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Insomnia ; Sleep disorder ; Power spectrum ; Spectrum analysis ; Electroencephalography ; Zolpidem ; Follow up study ; Human ; Electrophysiology ; Hypnotic ;

Mots-clés français / French Keywords

Insomnie ; Trouble sommeil ; Spectre puissance ; Analyse spectre ; Electroencéphalographie ; Zolpidem ; Etude longitudinale ; Homme ; Electrophysiologie ; Hypnotique ;

Mots-clés espagnols / Spanish Keywords

Insomnio ; Trastorno sueño ; Espectro potencia ; Análisis espectro ; Electroencefalografía ; Zolpidem ; Estudio longitudinal ; Hombre ; Electrofisiología ; Hipnótico ;

Localisation / Location

INIST-CNRS, Cote INIST : 18084, 35400009382681.0090