Titre du document / Document title

Efficacy and safety of terbinafine 1 % solution in the treatment of interdigital tinea pedis and tinea corporis or tinea cruris

Auteur(s) / Author(s)

The Terbinafine 1% Solution Group (SFF-351)
LEBWOHL Mark ⁽¹⁾ ; ELEWSKI Boni ⁽²⁾ ; EISEN Drore ; SAVIN Ronald C. ⁽³⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Mount Sinai Medical Center, New York City, ETATS-UNIS
⁽²⁾ University of Alabama School of Medicine, Birmingham, ETATS-UNIS
⁽³⁾ Yale University School of Medicine, New Haven, Connecticut, ETATS-UNIS

Résumé / Abstract

Two randomized, double-blind, vehicle-controlled, multicenter studies assessed the efficacy and safety of a new terbinafine 1% solution for the treatment of interdigital tinea pedis and tinea corporis or tinea cruris (tinea corporis/cruris). Patients with interdigital tinea pedis applied terbinafine 1% solution or vehicle twice daily for 1 week with 7 weeks of follow-up (N= 153) and patients with tinea corporis/ cruris applied terbinafine 1% solution or vehicle once daily for 1 week with 3 weeks of follow-up (N=66). Efficacy was assessed mycologically and clinically at the end of treatment and throughout follow-up. In the tinea pedis study, 66% of patients were effectively treated with terbinafine compared with 4% of the group treated by vehicle (P<.001; Mantel-Haenszel test). In the tinea corporis/cruris study, treatment was effective in 65% of the terbinafine group compared with 8% of the vehicle group (P<.001), There were no significant differences in the frequency of cutaneous adverse events between the 2 groups in either study. We conclude that one week of therapy with terbinafine 1% solution is highly effective, superior to vehicle, and safe for use in superficial fungal infections.

Revue / Journal Title

Cutis   ISSN 0011-4162   CODEN CUTIBC 

Source / Source

2001, vol. 67, n^o3, pp. 261-266 (6 ref.)

Langue / Language

Anglais

Editeur / Publisher

Quadrant HealthCom, Chatham, NJ, ETATS-UNIS  (1965) (Revue)

Mots-clés anglais / English Keywords

Terbinafine ; Toxicity ; Treatment efficiency ; Mycosis ; Local administration ; Percutaneous route ; Dermatophyte ; Skin ; Human ; Chemotherapy ; Amine ; Allylic compound ; Antifungal agent ; Infection ; Skin disease ;

Mots-clés français / French Keywords

Terbinafine ; Toxicité ; Efficacité traitement ; Mycose ; Voie locale ; Voie percutanée ; Dermatophyte ; Peau ; Homme ; Chimiothérapie ; Amine ; Composé allylique ; Antifongique ; Infection ; Peau pathologie ;

Mots-clés espagnols / Spanish Keywords

Terbinafina ; Toxicidad ; Eficacia tratamiento ; Micosis ; Vía local ; Vía percutánea ; Dermatofito ; Piel ; Hombre ; Quimioterapia ; Amina ; Compuesto alílico ; Antifúngico ; Infección ; Piel patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 17068, 35400009873390.0150