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Titre du document / Document title

Physical activity and risk of cognitive impairment and dementia in elderly persons

Auteur(s) / Author(s)

LAURIN Danielle (1 2) ; VERREAULT René (1 2) ; LINDSAY Joan (3 4) ; MACPHERSON Kathleen (5 6) ; ROCKWOOD Kenneth (5 6) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Laval University Geriatric Research Unit, Centre d'hébergement St-Augustin du Centre hospitalier affilie universitaire de Québec, Beauport, CANADA
(2) Department of Social and Preventive Medicine, Laval University, Sainte-Foy, Quebec, CANADA
(3) Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, CANADA
(4) Aging-Related Diseases Division, Laboratory Center for Disease Control, Health Canada, Ottawa, CANADA
(5) Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, CANADA
(6) Division of Geriatric Medicine, Dalhousie University, Queen Elizabeth II Health Sciences Center, Halifax, CANADA

Résumé / Abstract

Context: Dementia is common, costly, and highly age related. Little attention has been paid to the identification of modifiable lifestyle habits for its prevention. Objective: To explore the association between physical activity and the risk of cognitive impairment and dementia. Design, Setting, and Subjects: Data come from a community sample of 9008 randomly selected men and women 65 years or older, who were evaluated in the 1991-1992 Canadian Study of Health and Aging, a prospective cohort study of dementia. Of the 6434 eligible subjects who were cognitively normal at baseline, 4615 completed a 5-year follow-up. Screening and clinical evaluations were done at both waves of the study. In 1996-1997, 3894 remained without cognitive impairment, 436 were diagnosed as having cognitive impairment-no dementia, and 285 were diagnosed as having dementia. Main Outcome Measure: Incident cognitive impairment and dementia by levels of physical activity at baseline. Results: Compared with no exercise, physical activity was associated with lower risks of cognitive impairment, Alzheimer disease, and dementia of any type. Significant trends for increased protection with greater physical activity were observed. High levels of physical activity were associated with reduced risks of cognitive impairment (age-, sex-, and education-adjusted odds ratio, 0.58; 95% confidence interval, 0.41-0.83), Alzheimer disease (odds ratio, 0.50; 95% confidence interval, 0.28-0.90), and dementia of any type (odds ratio, 0.63; 95% confidence interval, 0.40-0.98). Conclusion: Regular physical activity could represent an important and potent protective factor for cognitive decline and dementia in elderly persons.

Revue / Journal Title

Archives of neurology    ISSN  0003-9942   CODEN ARNEAS 

Source / Source

2001, vol. 58, no 3 (179 p.)  (61 ref.), pp. 498-504

Langue / Language

Anglais

Editeur / Publisher

American Medical Association, Chicago, IL, ETATS-UNIS  (1960-2012) (Revue)

Mots-clés anglais / English Keywords

Cognitive disorder

;

Dementia

;

Physical exercise

;

Risk factor

;

Elderly

;

Human

;

Nervous system diseases

;

Neurological disorder

;

Mots-clés français / French Keywords

Trouble cognition

;

Démence

;

Exercice physique

;

Facteur risque

;

Personne âgée

;

Homme

;

Système nerveux pathologie

;

Trouble neurologique

;

Mots-clés espagnols / Spanish Keywords

Trastorno cognitivo

;

Demencia

;

Ejercicio físico

;

Factor riesgo

;

Anciano

;

Hombre

;

Sistema nervioso patología

;

Trastorno neurológico

;

Localisation / Location

INIST-CNRS, Cote INIST : 2048 B, 35400009803918.0220

Nº notice refdoc (ud4) : 943324



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