Titre du document / Document title

Naproxen availability from variable-dose and weight sustained-release tablets

Auteur(s) / Author(s)

AMARAL M. H. ⁽¹⁾ ; SOUSA LOBO J. M. ⁽¹⁾ ; FERREIRA D. C. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Centro de Tecnologia do Medicamento, Faculty of Pharmacy of OPorto, Rua Anibal Cunha, 164, 4050-Porto, PORTUGAL

Résumé / Abstract

The aim of this work was to compare the naproxen availability from hydroxypropyl methylcellulose (HPMC) matrix tablets containing the same dose and a 2-fold weight variation (160 mg of naproxen in tablets weighting 250 and 500 mg) or with the same weight and a 2-fold dose variation (500 mg of weight and 160 or 320 mg of naproxen). The 2-fold weight variation in tablets with the same dose and also the 2-fold dose variation in tablets with the same weight did not affect the naproxen release. In addition, the release rate of two tablets of the same formulation and one tablet with a 2-fold dose and weight variation was not significantly different at the first minutes of the dissolution assay.

Revue / Journal Title

Drug development and industrial pharmacy   ISSN 0363-9045 

Source / Source

2001, vol. 27, n^o3, pp. 221-225 (11 ref.)

Langue / Language

Anglais

Editeur / Publisher

Taylor & Francis, Colchester, ROYAUME-UNI  (1977) (Revue)

Mots-clés anglais / English Keywords

Naproxen ; Non steroidal antiinflammatory agent ; Dosage form ; Controlled release form ; Release ; Active ingredient ; Hypromellose ; Dissolution ; Mass ; Dose ; Tablet ; Solubility ; In vitro ; Mathematical model ; Arylpropionic acid derivatives ;

Mots-clés français / French Keywords

Naproxène ; Antiinflammatoire non stéroïde ; Forme pharmaceutique ; Forme libération contrôlée ; Libération ; Principe actif ; Hypromellose ; Dissolution ; Masse ; Dose ; Comprimé ; Solubilité ; In vitro ; Modèle mathématique ; Arylpropionique acide dérivé ;

Mots-clés espagnols / Spanish Keywords

Naproxeno ; Antiinflamatorio no esteroide ; Forma farmacéutica ; Forma liberación controlada ; Liberación ; Principio activo ; Hipromelosa ; Disolución ; Masa ; Dosis ; Tableta ; Solubilidad ; In vitro ; Modelo matemático ; Arilpropionico ácido derivado ;

Localisation / Location

INIST-CNRS, Cote INIST : 17132, 35400009454365.0050