Titre du document / Document title

Effects of alprazolam, caffeine, and zolpidem in humans trained to discriminate triazolam from placebo

Auteur(s) / Author(s)

SMITH Brandi J. ; BICKEL Warren K. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT 05401, ETATS-UNIS

Résumé / Abstract

This study compared the discriminative stimulus effects of zolpidem, a nonbenzodiazepine hypnotic, to benzodiazepines. Eight participants learned to discriminate triazolam (0.35 mg/70 kg) from placebo. The discriminative stimulus effects, self-reported subjective effects, and performance effects of triazolam (0.05-0.35 mg/70 kg), alprazolam (0.25-1.75 mg/70 kg), zolpidem (2.5-35 mg/70 kg) and caffeine (75-525 mg/70 kg) were assessed under two-response and novel-response drug discrimination procedures. Under the two-response procedure, triazolam, alprazolam and zolpidem fully substitued for triazolam and caffeine did not. Under the novel-response procedure, triazolam and alprazolam substituted for triazolam and zolpidem partially substituted for triazolam. Zolpidem, but not triazolam or alprazolam, also produced some novel responding. Caffeine produced both placebo-appropriate and novel responding. The self-reported effects of triazolam, alprazolam and zolpidem were similar. Overall, zolpidem produced similar, but not identical, effects as the benzodiazepines.

Revue / Journal Title

Drug and alcohol dependence   ISSN 0376-8716   CODEN DADEDV 

Source / Source

2001, vol. 61, n^o3, pp. 249-260 (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Shannon, IRLANDE  (1975) (Revue)

Mots-clés anglais / English Keywords

Comparative study ; Stimulus discrimination ; Treatment efficiency ; Zolpidem ; Hypnotic ; Sedative ; Alprazolam ; Psychotropic ; Tranquillizer ; Triazolam ; Chemotherapy ; Questionnaire ; Caffeine ; Volunteer ; Healthy subject ; Digit Symbol Substitution Test ; Visual Analogue Scale Crichton ; Addiction Research Center Inventory ; Discrimination task ; Adult ; Subjective evaluation ; Statistical analysis ; Performance evaluation ; Benzodiazepine derivatives ; Xanthine derivatives ; Technique ; Human ;

Mots-clés français / French Keywords

Etude comparative ; Discrimination stimulus ; Efficacité traitement ; Zolpidem ; Hypnotique ; Sédatif ; Alprazolam ; Psychotrope ; Tranquillisant ; Triazolam ; Chimiothérapie ; Questionnaire ; Caféine ; Volontaire ; Individu sain ; Digit Symbol Substitution Test ; Visual Analogue Scale Crichton ; Addiction Research Center Inventory ; Tâche discrimination ; Adulte ; Evaluation subjective ; Analyse statistique ; Evaluation performance ; Benzodiazépine dérivé ; Xanthine dérivé ; Technique ; Imidazo pyridine dérivé ; Homme ;

Mots-clés espagnols / Spanish Keywords

Estudio comparativo ; Discriminación estímulo ; Eficacia tratamiento ; Zolpidem ; Hipnótico ; Sedante ; Alprazolam ; Psicotropo ; Tranquilizante ; Triazolam ; Quimioterapia ; Cuestionario ; Cafeína ; Voluntario ; Individuo sano ; Digit Symbol Substitution Test ; Visual Analogue Scale Crichton ; Addiction Research Center Inventory ; Tarea discriminatoria ; Adulto ; Evaluación subjetiva ; Análisis estadístico ; Evaluación prestación ; Benzodiazepina derivado ; Xantina derivado ; Técnica ; Hombre ;

Localisation / Location

INIST-CNRS, Cote INIST : 16471, 35400009401341.0060