RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Spectroscopic characterization of ozonides with biological activity

Auteur(s) / Author(s)

DIAZ Maritza (1) ; LEZCANO Irene (1) ; MOLERIO Jesus (1) ; HERNANDEZ Frank (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Ozone Research Center, National Center for Scientific Research, P.O. Box 6990, Havana, CUBA

Résumé / Abstract

Ozonation reactions are very important in fatty acid chemistry since their ozonation products are involved in vital biological processes. When an unsaturated acid reacts with ozone in presence of an organic solvent, Criegee ozonides are produced according to the Criegee mechanism. These ozonides are relatively stable compounds, thus, in the organism they have biological effects at distant sites from the site they are formed. The antimicrobial activity of ozonized sunflower oil (OleozonR) has been previously well documented. We have suggested that ozonides are involved in the antimicrobial effect of OleozonR. In this study we try to demonstrate this hypothesis. Ozonides were obtained by total reaction of ozone gas with a sample of methyl oleate in an organic solvent (hexane). Proton Nuclear Magnetic Resonance (1H NMR) technique was used for identification of ozonides in ozonation products, whereas biological evaluation was done by determining Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) of ozonation products of different microorganism. The ozonide signal was identified in the OleozonR and ozonized methyl oleate while in sunflower oil was not. Ozonation products from methyl oleate, in our reaction conditions, were spectroscopically found to be only ozonides. MICs for ozonides from ozonized methyl oleate were from 2.3 to 28 mg/mL, whereas MBC and MFC were 460 mg/mL comparable with those from OleozonR. These results demonstrate that ozonides are one of the active species of OleozonR.

Revue / Journal Title

Ozone : science & engineering    ISSN  0191-9512   CODEN OZSEDS 

Source / Source

2001, vol. 23, no1, pp. 35-40 (22 ref.)

Langue / Language

Anglais

Editeur / Publisher

Taylor & Francis, Philadelphia, PA, ETATS-UNIS  (1979) (Revue)

Mots-clés anglais / English Keywords

Fatty ester

;

Unsaturated fatty acid

;

Chemical treatment

;

Ozonization

;

Ozone

;

Ozonides

;

Hexane

;

Biological activity

;

NMR spectrometry

;

Antifungal agent

;

Antibacterial agent

;

Experimental study

;

Mots-clés français / French Keywords

Ester gras

;

Acide gras insaturé

;

Traitement chimique

;

Ozonation

;

Ozone

;

Ozonide

;

Hexane

;

Activité biologique

;

Spectrométrie RMN

;

Antifongique

;

Antibactérien

;

Etude expérimentale

;

Oléique acide ester méthyle

;

Mots-clés espagnols / Spanish Keywords

Ester graso

;

Acido graso no saturado

;

Tratamiento químico

;

Ozonización

;

Ozono

;

Ozónido

;

Hexano

;

Actividad biológica

;

Espectrometría RMN

;

Antifúngico

;

Antibacteriano

;

Estudio experimental

;

Localisation / Location

INIST-CNRS, Cote INIST : 18256, 35400009800294.0030

Nº notice refdoc (ud4) : 895505



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas