Titre du document / Document title

Effect of praziquantel on the strobilar development of Mesocestoides corti in vitro

Auteur(s) / Author(s)

BRITOS L. ⁽¹⁾ ; DOMINGUEZ L. ⁽²⁾ ; EHRLICH R. ⁽¹⁾ ; MARIN M. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Facultad de Ciencias, Sección Bioquímica, Iguá 4225, Montevideo 11400, URUGUAY
⁽²⁾ Facultad de Química, Departamento de Farmacología, Gral Flores 2124, Montevideo, URUGUAY

Résumé / Abstract

The effect of praziquantel (PZQ) on the strobilar development of the cyclophyllidean cestode Mesocestoides corti was explored. Mesocestoides corti larvae were cultivated under conditions reported to favour their differentiation to the adult stage. Parasites were exposed to 0.1 μg ml^-1 PZQ for 16 h and subsequently transferred to drug-free medium. The ocurrence of segmentation -an early event of the larval somatic differentiation to the adult worm - was considered as quantitative data. This phenomenon was evidenced earlier in worms transiently exposed to PZQ with respect to control cultures. Moreover, the rate of segmentation of drug-treated worms at the end of the experiment almost doubled that of control worms. To date, no similar effect on any cestode developmental process has been reported for an anthelmintic drug. In the light of the existing knowledge and understanding of PZQ mechanisms of action, the proposed experimental approach could contribute to the elucidation of pathways and mechanisms involved in cestode strobilar development.

Revue / Journal Title

Journal of helminthology   ISSN 0022-149X   CODEN JOHLAT 

Source / Source

2000, vol. 74, n^o4, pp. 295-299 (20 ref.)

Langue / Language

Anglais

Editeur / Publisher

Cambridge University Press, Oxon, ROYAUME-UNI  (1923) (Revue)

Mots-clés anglais / English Keywords

Sublethal dose ; Praziquantel ; Anthelmintic ; Development ; Parasite ; Zoopathogen ; In vitro ; Mesocestoides corti ; Parasiticid ; Host parasite relation ; Cestoda ; Plathelmintha ; Helmintha ; Invertebrata ;

Mots-clés français / French Keywords

Dose sublétale ; Praziquantel ; Anthelminthique ; Développement ; Parasite ; Zoopathogène ; In vitro ; Mesocestoides corti ; Antiparasitaire ; Relation hôte parasite ; Cestoda ; Plathelmintha ; Helmintha ; Invertebrata ;

Mots-clés espagnols / Spanish Keywords

Dosis subletal ; Prazicuantel ; Antihelmíntico ; Desarrollo ; Parásito ; Zoopatógeno ; In vitro ; Mesocestoides corti ; Antiparasitario ; Relación huesped parásito ; Cestoda ; Plathelmintha ; Helmintha ; Invertebrata ;

Localisation / Location

INIST-CNRS, Cote INIST : 6411, 35400009409781.0030