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Titre du document / Document title

A quantitative MR measure of the fornix in schizophrenia

Auteur(s) / Author(s)

ZAHAJSZKY Janos (1) ; DICKEY Chandlee C. (2) ; MCCARLEY Robert W. (2) ; FISCHER Iris A. (2) ; NESTOR Paul (2) ; KIKINIS Ron (3) ; SHENTON Martha E. (2 3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Mount Sinai Medical School, New York, NY 10029, ETATS-UNIS
(2) Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, VAMC, 940 Belmont Street, Brockton, MA 02301, ETATS-UNIS
(3) Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, ETATS-UNIS

Résumé / Abstract

Some cognitive disturbances accompanying schizophrenia may be due to abnormalities in the thalamus and components of the limbic system. The fornix is an important white-matter relay pathway connecting these structures and is likely to be affected in schizophrenia as well. Magnetic resonance images of the fornix were analyzed in 15 schizophrenic patients and 15 matched comparison group subjects. Fornix volume was compared between the two groups and was also correlated with the volumes of other neuroanatomical structures, as well as with illness presentation, clinical status, and cognitive/psychological measures. There was no significant difference in fornix volume between the two groups. Of note, fornix volume correlated significantly with the volumes of the hippocampus, parahippocampus, and the superior temporal gyrus in the schizophrenic subjects, but not in the controls. Moreover, the correlation between fornix and parahippocampal gyrus volumes differed significantly between the two groups. No association was found between fornix volume and illness presentation or between fornix and cognitive/clinical measures. Results suggest that there are no marked changes in fornix volume in schizophrenia by MRI. The fornix, however, may be part of a network of structures affected in schizophrenia, as indicated by correlated volumetric changes.

Revue / Journal Title

Schizophrenia research    ISSN  0920-9964 

Source / Source

2001, vol. 47, no1, pp. 87-97 (1 p.1/2)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1988) (Revue)

Mots-clés anglais / English Keywords

Schizophrenia

;

Symptomatology

;

Comparative study

;

Nuclear magnetic resonance imaging

;

Volumetric analysis

;

Fornix

;

Hippocampus

;

Brain (vertebrata)

;

Central nervous system

;

Young adult

;

Adult

;

Human

;

Psychosis

;

Medical imagery

;

Mots-clés français / French Keywords

Schizophrénie

;

Symptomatologie

;

Etude comparative

;

Imagerie RMN

;

Volumétrie

;

Fornix

;

Hippocampe

;

Encéphale

;

Système nerveux central

;

Adulte jeune

;

Adulte

;

Homme

;

Psychose

;

Imagerie médicale

;

Mots-clés espagnols / Spanish Keywords

Esquizofrenia

;

Sintomatología

;

Estudio comparativo

;

Imageria RMN

;

Volumetría

;

Trígono cerebral

;

Hipocampo

;

Encéfalo

;

Sistema nervioso central

;

Adulto joven

;

Adulto

;

Hombre

;

Psicosis

;

Imageneria medical

;

Localisation / Location

INIST-CNRS, Cote INIST : 21734, 35400009490120.0090

Nº notice refdoc (ud4) : 882088



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