RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Relation between dosage of carbamazepine and concentration in hair and plasma samples from a compliant inpatient epileptic population

Auteur(s) / Author(s)

WILLIAMS John (1) ; PATSALOS Philip N. (2) ; ZHANG MEI (1) ; SCHAPEL Graham (1) ; WILSON John F. (1) ; RICHENS Alan (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pharmacology, Therapeutics and Toxicology, University of Wales College of Medicine, Cardiff, Wales, ROYAUME-UNI
(2) Pharmacology and Therapeutics Unit, National Society for Epilepsy, Chalfont St. Peter, Gerrards Cross, Buckinghamshire, ROYAUME-UNI

Résumé / Abstract

Compliance is a problem in all areas of therapeutic medicine. Methods for its assessment are classified as either indirect or direct. Indirect assessment is based on criteria such as pill counts, questionnaires, and self-reporting; direct methods involve the analytic measurement of the drugs in biologic fluids such as plasma or urine. Drugs taken either therapeutically or recreationally become incorporated into hair. This prospective study investigated the relation between the daily intake of the antiepileptic drug carbamazepine and both its trough plasma and hair concentrations in a highly supervised inpatient population of patients with epilepsy during a period of 6 months. Results showed that although there was a significant variation between patients resulting from the substantial range in the daily intake of carbamazepine (800-2400 mg/day), the intrapatient variation in both trough plasma and hair concentrations during the 6-month period were not significantly different. The mean intrapatient percentage coefficient of variation in total plasma and hair concentrations of carbamazepine was 11.5 ± 4.7 and 15.0 ± 5.2, respectively, both of which were independent of the daily dosage. This relatively small intrapatient variation in hair concentration over time and its close relation to the plasma concentration suggests that hair analysis may be a complementary and useful technique in monitoring drug-taking behavior.

Revue / Journal Title

Therapeutic drug monitoring    ISSN  0163-4356   CODEN TDMODV 

Source / Source

2001, vol. 23, no1, pp. 15-20 (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS  (1979) (Revue)

Mots-clés anglais / English Keywords

Carbamazepine

;

Epilepsy

;

Anticonvulsant

;

Chemotherapy

;

Treatment

;

Human

;

Oral administration

;

Pharmacokinetics

;

Blood plasma

;

Hair (head)

;

Drug compliance

;

Tricyclic compound

;

Dibenzazepine derivatives

;

Nervous system diseases

;

Central nervous system disease

;

Cerebral disorder

;

Mots-clés français / French Keywords

Carbamazépine

;

Epilepsie

;

Anticonvulsivant

;

Chimiothérapie

;

Traitement

;

Homme

;

Voie orale

;

Pharmacocinétique

;

Plasma sanguin

;

Cheveu

;

Observance médicamenteuse

;

Composé tricyclique

;

Dibenzo azépine dérivé

;

Système nerveux pathologie

;

Système nerveux central pathologie

;

Encéphale pathologie

;

Mots-clés espagnols / Spanish Keywords

Carbamazepina

;

Epilepsia

;

Anticonvulsivante

;

Quimioterapia

;

Tratamiento

;

Hombre

;

Vía oral

;

Farmacocinética

;

Plasma sanguíneo

;

Cabello

;

Observancia de la medicación

;

Compuesto tricíclico

;

Sistema nervioso patología

;

Sistema nervosio central patología

;

Encéfalo patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 18087, 35400009394926.0040

Nº notice refdoc (ud4) : 861731



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas