Titre du document / Document title

Usefulness of cardiovascular family history data for population-based preventive medicine and medical research (the Health Family Tree Study and the NHLBI Family Heart study)

Auteur(s) / Author(s)

WILLIAMS Roger R. ; HUNT Steven C. ; HEISS Gerardo ; PROVINCE Michael A. ; BENSEN Jeannette T. ; HIGGINS Millicent ; CHAMBERLAIN Robert M. ; WARE Joan ; HOPKINS Paul N. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Cardiovascular Genetics Research Clinic, University of Utah School of Medicine, Salt Lake City, Utah, ETATS-UNIS
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, ETATS-UNIS
Division of Biostatistics, Washington University, St. Louis, Missouri, ETATS-UNIS
Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, North Carolina, ETATS-UNIS
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, ETATS-UNIS
Department of Epidemiology, University of Texas, M.D Anderson Cancer Center, Houston, Texas, ETATS-UNIS
Bureau of Chronic Disease Control Utah Department of Health, Salt Lake City, Utah, ETATS-UNIS

Résumé / Abstract

Detailed medical family history data have been proposed to be effective in identifying high-risk families for targeted intervention. With use of a validated and standardized quantitative family risk score (FRS), the degree of familial aggregation of coronary heart disease (CHD), stroke, hypertension, and diabetes was obtained from 122,155 Utah families and 6,578 Texas families in the large, population-based Health Family Tree Study, and 1,442 families in the NHLBI Family Heart Study in Massachusetts, Minnesota, North Carolina, and Utah. Utah families with a positive family history of CHD (FRS ≥0.5) represented only 14% of the general population but accounted for 72% of persons with early CHD (men before age 55 years, women before age 65 years) and 48% of CHD at all ages. For strokes, 11% of families with FRS ≥0.5 accounted for 86% of early strokes (<75 years) and 68% of all strokes. Analyses of >5,000 families sampled each year in Utah for 14 years demonstrated a gradual decrease in the frequency of a strong positive family history of CHD (-26%/decade) and stroke (-15%/decade) that paralleled a decrease in incidence rates (r = 0.86, p <0.001 for CHD; r = 0.66, p <0.01 for stroke). Because of the collaboration of schools, health departments, and medical schools, the Health Family Tree Study proved to be a highly cost-efficient method for identifying 17,064 CHD-prone families and 13,106 stroke-prone families (at a cost of about $27 per high-risk family) in whom well-established preventive measures can be encouraged. We conclude that most early cardiovascular events in a population occur in families with a positive family history of cardiovascular disease. Family history collection is a validated and relatively inexpensive tool for family-based preventive medicine and medical research.

Revue / Journal Title

The American journal of cardiology   ISSN 0002-9149   CODEN AJCDAG 

Source / Source

2001, vol. 87, n^o2, pp. 129-135 (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1958) (Revue)

Mots-clés anglais / English Keywords

Coronary heart disease ; Family story ; Stroke ; Preventive medicine ; Risk factor ; Human ; Cardiovascular disease ; Nervous system diseases ; Central nervous system disease ; Cerebral disorder ; Cerebrovascular disease ; Vascular disease ;

Mots-clés français / French Keywords

Cardiopathie coronaire ; Histoire familiale ; Accident cérébrovasculaire ; Médecine préventive ; Facteur risque ; Homme ; Appareil circulatoire pathologie ; Système nerveux pathologie ; Système nerveux central pathologie ; Encéphale pathologie ; Cérébrovasculaire pathologie ; Vaisseau sanguin pathologie ;

Mots-clés espagnols / Spanish Keywords

Cardiopatía coronaria ; Historia familiar ; Accidente cerebrovascular ; Medicina preventiva ; Factor riesgo ; Hombre ; Aparato circulatorio patología ; Sistema nervioso patología ; Sistema nervosio central patología ; Encéfalo patología ; Vaso sanguíneo encéfalo patología ; Vaso sanguíneo patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 8674, 35400009395147.0010