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Titre du document / Document title

Carbofuran-induced delayed neuropathy

Auteur(s) / Author(s)

YANG Po-Yi (1) ; TSAO Thomas C. Y. (1) ; LIN Ja-Liang (1) ; LYU Rong-Kuo (1) ; CHIANG Ping-Cherng (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Chang Gung Memorial Hospital, Taipei, TAIWAN, PROVINCE DE CHINE

Résumé / Abstract

Background: Although carbamates have been widely used in the world for many years, carbamate-induced delayed neuropathy is rare. We report what appears to be delayed neuropathy caused by poisoning with carbofuran, a cholinesterase-inhibiting carbamate, although the certainty of diagnosis is somewhat limited by the lack of a sural nerve biopsy and spinal fluid examination. Case Report: A 23-year-old man attempted suicide by ingesting 100 mL of carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate). After recovering from acute cholinergic toxicity, he had notable paresthesia in his lower limbs and difficulty walking. Electrophysiologic findings revealed sensorimotor neuropathy. Recovery began at 1 week and continued for 4 months. A similar delayed neuropathy has been described with carbamate, 1-naphthyl N-methylcarbamate, and m-tolyl methylcarbamate, but not with carbofuran insecticides.

Revue / Journal Title

Journal of toxicology. Clinical toxicology    ISSN  0731-3810 

Source / Source

2000, vol. 38, no1, pp. 43-46 (12 ref.)

Langue / Language

Anglais

Editeur / Publisher

Dekker, Monticello, NY, ETATS-UNIS  (1982-2004) (Revue)

Mots-clés anglais / English Keywords

Carbofuran

;

Delayed toxicity

;

Neuropathy

;

Poisoning

;

Case study

;

Human

;

Suicide

;

Anticholinesterase agent

;

Carbamate

;

Insecticide

;

Pesticides

;

Nervous system diseases

;

Mots-clés français / French Keywords

Carbofuran

;

Toxicité retardée

;

Neuropathie

;

Intoxication

;

Etude cas

;

Homme

;

Suicide

;

Anticholinestérasique

;

Carbamate

;

Insecticide

;

Pesticide

;

Système nerveux pathologie

;

Mots-clés espagnols / Spanish Keywords

Carbofurano

;

Toxicidad retardada

;

Neuropatía

;

Intoxicación

;

Estudio caso

;

Hombre

;

Suicidio

;

Anticolinesterasa agente

;

Carbamato

;

Insecticida

;

Plaguicida

;

Sistema nervioso patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 14107 A, 35400009444333.0070

Nº notice refdoc (ud4) : 850807



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