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Titre du document / Document title

Dopamine D4 receptor (DRD4) gene polymorphism is associated with attachment disorganization in infants

Auteur(s) / Author(s)

LAKATOS K. (1) ; TOTH I. (1) ; NEMODA Z. (2) ; NEY K. (1) ; SASVARI-SZEKELY M. (2) ; GERVAI J. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Social Development Group, Institute of Psychology, Hungarian Academy of Sciences, POB 398, Budapest, 1394, HONGRIE
(2) Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, POB 260, Budapest, 1444, HONGRIE

Résumé / Abstract

About 15% of one-year-old infants in non-clinical, low-risk and up to 80% in high-risk (eg maltreated) populations show extensive disorganized attachment behavior1,2 in the Strange Situation Test.3 It has also been reported that disorganization of early attachment is a major risk factor for the development of childhood behavior problems.4 The collapse of organized attachment strategy has been explained primarily by inappropriate caregiving, but recently, the contribution of child factors such as neurological impairments and neonatal behavioral organlzation6 has also been suggested. Here we report an association between the DRD4 III exon 48-bp repeat polymorphism and attachment disorganization. Attachment behavior of 90 infants was tested in the Strange Situation and they were independently genotyped for the number of the 48-bp repeats by polymerase chain reaction (PCR). The 7-repeat allele was represented with a significantly higher frequency in infants classified as disorganized compared to non-disorganized infants: 12 of 17 (71%) vs 21 of 73 (29%) had at least one 7-repeat allele (X2 = 8.66, df = 1, P < 0.005). The estimated relative risk for disorganized attachment among children carrying the 7-repeat allele was 4.15. We suggest that, in non-clinical, low-social-risk populations, having a 7-repeat allele predisposes infants to attachment disorganization.

Revue / Journal Title

Molecular psychiatry    ISSN  1359-4184 

Source / Source

2000, vol. 5, no6, pp. 633-637 (34 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing Group, Basingstoke, ROYAUME-UNI  (1996) (Revue)

Mots-clés anglais / English Keywords

Polymorphism

;

Gene

;

D4 Dopamine receptor

;

Child

;

Affective attachment

;

Social interaction

;

Parental behavior

;

Risk factor

;

Bulgaria

;

Affect affectivity

;

Predisposition

;

Human

;

Europe

;

Mots-clés français / French Keywords

Polymorphisme

;

Gène

;

Récepteur dopaminergique D4

;

Enfant

;

Attachement affectif

;

Interaction sociale

;

Comportement parental

;

Facteur risque

;

Bulgarie

;

Affect affectivité

;

Prédisposition

;

Trouble attachement

;

Homme

;

Europe

;

Mots-clés espagnols / Spanish Keywords

Polimorfismo

;

Gen

;

Receptor dopaminérgico D4

;

Niño

;

Apego afectivo

;

Interacción social

;

Conducta parental

;

Factor riesgo

;

Bulgaria

;

Afecto afectividad

;

Predisposición

;

Hombre

;

Europa

;

Localisation / Location

INIST-CNRS, Cote INIST : 26439, 35400009155921.0050

Nº notice refdoc (ud4) : 846144



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