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Titre du document / Document title

The injection of nodules of Dupuytren's disease with triamcinolone acetonide

Auteur(s) / Author(s)

KETCHUM Lynn D. (1) ; DONAHUE Terrence K. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Surgery, Menorah Medical Center, Overland Park, KS, ETATS-UNIS

Résumé / Abstract

Over a 4-year period 63 patients (75 hands) with Dupuytren's nodules were treated with a series of injections with the steroid triamcinolone acetonide directly into the area of disease. The purpose of this study was to determine whether intralesional injections of triamcinolone acetonide could produce softening and flattening in nodules of Dupuytren's disease as seen in the intralesional injections of hypertrophic scars and keloids. After an average of 3.2 injections per nodule 97% of the hands showed regression of disease as exhibited by a softening or flattening of the nodule(s). Although some patients had complete resolution of the nodules, most experienced definite but incomplete resolution of the nodules in the range of 60% to 80%. Although a few patients did not experience recurrence or reactivation of the disease in the injected nodules or development of new nodules, 50% of patients did experience reactivation of disease in the nodules 1 to 3 years after the last injection, necessitating 1 or more injections. The findings of this study indicate that the intralesional injection of nodules of Dupuytren's disease with triamcinolone acetonide may modify the progression of the disease.

Revue / Journal Title

The Journal of hand surgery    ISSN  0363-5023   CODEN JHSUDV 

Source / Source

2000, vol. 25A, no6, pp. 1157-1162 (9 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1976) (Revue)

Mots-clés anglais / English Keywords

Dupuytren contracture

;

Treatment

;

Technique

;

Nodule

;

Injection

;

Intralesional administration

;

Treatment efficiency

;

Human

;

Instrumentation therapy

;

Upper limb

;

Corticosteroid

;

Diseases of the osteoarticular system

;

Juxtaarticular disease

;

Disease of the hand

;

Mots-clés français / French Keywords

Main Dupuytren maladie

;

Traitement

;

Technique

;

Nodule

;

Injection

;

Voie intralésionnelle

;

Triamcinolone acétonide

;

Efficacité traitement

;

Homme

;

Traitement instrumental

;

Membre supérieur

;

Corticostéroïde

;

Système ostéoarticulaire pathologie

;

Juxtaarticulaire pathologie

;

Main pathologie

;

Mots-clés espagnols / Spanish Keywords

Contracción Dupuytren

;

Tratamiento

;

Técnica

;

Nódulo

;

Inyección

;

Vía intralesional

;

Eficacia tratamiento

;

Hombre

;

Tratamiento instrumental

;

Miembro superior

;

Corticoesteroide

;

Sistema osteoarticular patología

;

Yuxtaarticular patología

;

Mano patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 17094, 35400009344640.0210

Nº notice refdoc (ud4) : 835106



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