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Titre du document / Document title

Effects of near-infrared low-level laser irradiation on microcirculation

Auteur(s) / Author(s)

MAEGAWA Yasuyo (1) ; ITOH Toshiyuki (2) ; HOSOKAWA Toyoshi (1) ; YAEGASHI Kazuhiro (2) ; NISHI Mayumi (3) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, JAPON
(2) Department of Physiology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, JAPON
(3) Department of Anatomy, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, JAPON

Résumé / Abstract

Background and Objective: Recently, there has been an increase in the clinical application of low-level laser irradiation (LLLI) in various fields. The present study was conducted to explore the effects of LLLI on microcirculation. Study Design/Material and Methods: We investigated the effects of LLLI on rat mesenteric microcirculation in vivo, and on cytosolic calcium concentration ([Ca2+]i) in rat vascular smooth muscle cells (VSMCs) in vitro. Results: LLLI caused potent dilation in the laser-irradiated arteriole, which led to marked increases in the arteriolar blood flow. The changes were partly attenuated in the initial phase by the superfusion of 15 μM L-NAME, but they were not affected by local denervation. Furthermore, LLLI caused a power-dependent decrease in [Ca2+]i in VSMCs. Conclusion: The circulatory changes observed seemed to be mediated largely by LLLI-induced reduction of [Ca2+]i in VSMCs, in addition to the involvement of NO in the initial phase.

Revue / Journal Title

Lasers in surgery and medicine    ISSN  0196-8092   CODEN LSMEDI 

Source / Source

2000, vol. 27, no5, pp. 427-437 (28 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley-Liss, New York, NY, ETATS-UNIS  (1980) (Revue)

Mots-clés anglais / English Keywords

Near infrared radiation

;

Infrared laser

;

Biological effect

;

Vascularization

;

Animal model

;

Animal

;

Rat

;

Mesentery

;

In vivo

;

Concentration

;

Calcium ion

;

Smooth muscle

;

Blood vessel

;

Correlation

;

Hemodynamics

;

Rodentia

;

Mammalia

;

Vertebrata

;

Circulatory system

;

Mots-clés français / French Keywords

Rayonnement IR proche

;

Laser IR

;

Effet biologique

;

Vascularisation

;

Modèle animal

;

Animal

;

Rat

;

Mésentère

;

In vivo

;

Concentration

;

Calcium ion

;

Muscle lisse

;

Vaisseau sanguin

;

Corrélation

;

Hémodynamique

;

Microvascularisation

;

Rodentia

;

Mammalia

;

Vertebrata

;

Appareil circulatoire

;

Mots-clés espagnols / Spanish Keywords

Radiación infrarroja cercana

;

Laser IR

;

Efecto biológico

;

Vascularización

;

Modelo animal

;

Animal

;

Rata

;

Mesenterio

;

In vivo

;

Concentración

;

Calcio ión

;

Músculo liso

;

Vaso sanguíneo

;

Correlación

;

Hemodinámica

;

Rodentia

;

Mammalia

;

Vertebrata

;

Aparato circulatorio

;

Localisation / Location

INIST-CNRS, Cote INIST : 18391, 35400009279242.0050

Nº notice refdoc (ud4) : 821243



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