Titre du document / Document title

Strong amerind/white sex bias and a possible Sephardic contribution among the founders of a population in Northwest Colombia

Auteur(s) / Author(s)

CARVAJAL-CARMONA Luis G. ^{(1 2)} ; SOTO Ivan D. ⁽¹⁾ ; PINEDA Nicolas ⁽¹⁾ ; ORTIZ-BARRIENTOS Daniel ⁽¹⁾ ; DUQUE Constanza ⁽¹⁾ ; OSPINA-DUQUE Jorge ⁽³⁾ ; MCCARTHY Mark ⁽⁴⁾ ; MONTOYA Patricia ^{(1 2 3 5)} ; ALVAREZ Victor M. ⁽⁵⁾ ; BEDOYA Gabriel ⁽¹⁾ ; RUIZ-LINARES Andrés ^{(1 2 3)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Laboratorio de Genética Molecular, Universidad de Antioquia, Medellín, COLOMBIE
⁽²⁾ Department of Medical and Community Genetics, Imperial College School of Medicine, Northwick Park Hospital, Harrow, ROYAUME-UNI
⁽³⁾ Departamento de Psiquiatría, Universidad de Antioquia, Medellín, COLOMBIE
⁽⁴⁾ Complex Trait Analysis Group, Imperial College Genetics and Genomics Research Institute, Imperial College School of Medicine (Hammersmith Campus), London, ROYAUME-UNI
⁽⁵⁾ Departamento de Historia, Universidad de Antioquia, Medellín, COLOMBIE

Résumé / Abstract

Historical and genetic evidences suggest that the recently founded population of Antioquia (Colombia) is potentially useful for the genetic mapping of complex traits. This population was established in the 16th-17th centuries through the admixture of Amerinds, Europeans, and Africans and grew in relative isolation until the late 19th century. To examine the origin of the founders of Antioquia, we typed 11 markers on the nonrecombining portion of the Y chromosome and four markers on mtDNA in a sample of individuals with confirmed Antioquian ancestry. The polymorphisms on the Y chromosome (five biallelic markers and six microsatellites) allow an approximation to the origin of founder men, and those on mtDNA identify the four major founder Native American lineages. These data indicate that ∼94% of the Y chromosomes are European, 5% are African, and 1% are Amerind. Y-chromosome data are consistent with an origin of founders predominantly in southern Spain but also suggest that a fraction came from northern Iberia and that some possibly had a Sephardic origin. In stark contrast with the Y-chromosome, ∼90% of the mtDNA gene pool of Antioquia is Amerind, with the frequency of the four Amerind founder lineages being closest to Native Americans currently living in the area. These results indicate a highly asymmetric pattern of mating in early Antioquia, involving mostly immigrant men and local native women. The discordance of our data with blood-group estimates of admixture suggests that the number of founder men was larger than that of women.

Revue / Journal Title

American journal of human genetics   ISSN 0002-9297   CODEN AJHGAG 

Source / Source

2000, vol. 67, n^o5, pp. 1287-1295 (1 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

University of Chicago Press, Chicago, IL, ETATS-UNIS  (1949) (Revue)

Mots-clés anglais / English Keywords

Colombia ; Human ; Founder effect ; Mitochondrial DNA ; Y-Chromosome ; Exploration ; Amerindian ; Male ; Female ; Sex ; Polymorphism ; Ethnic origin ; South America ; America ; Population genetics ; Anthropology ;

Mots-clés français / French Keywords

Colombie ; Homme ; Effet fondateur ; DNA mitochondrial ; Chromosome Y ; Exploration ; Amérindien ; Mâle ; Femelle ; Sexe ; Polymorphisme ; Origine ethnique ; Amérique du Sud ; Amérique ; Génétique population ; Anthropologie ;

Mots-clés espagnols / Spanish Keywords

Colombia ; Hombre ; Efecto fundador ; DNA mitocondrial ; Cromosoma Y ; Exploración ; Amerindio ; Macho ; Hembra ; Sexo ; Polimorfismo ; Origen étnico ; America del sur ; America ; Genética población ; Antropología ;

Localisation / Location

INIST-CNRS, Cote INIST : 2610, 35400009277451.0230