Titre du document / Document title

Monotherapy with amlodipine or atenolol versus their combination in stable angina pectoris

Auteur(s) / Author(s)

PEHRSSON S. Kenneth ⁽¹⁾ ; RINGQVIST Ivar ⁽²⁾ ; EKDAHL Sten ⁽³⁾ ; KARLSON Björn W. ⁽⁴⁾ ; ULVENSTAM Göran ⁽⁵⁾ ; PERSSON Stig ⁽⁶⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Cardiology, Karolinska Hospital, Stockholm, SUEDE
⁽²⁾ Department of Clinical Physiology, Central Hospital, Västerås, SUEDE
⁽³⁾ Department of Medicine, Eksjö Hospital, Eksjö, SUEDE
⁽⁴⁾ Department of Medicine, Uddevalla Hospital, Uddevalla, SUEDE
⁽⁵⁾ Department of Medicine, Lundby Hospital, Gothenburg, SUEDE
⁽⁶⁾ Department of Cardiology, University Hospital, Malmö, SUEDE

Résumé / Abstract

Background: The basic cause of angina pectoris is imbalance between the metabolic needs of the myocardium and the capacity of the coronary circulation to deliver sufficient oxygenated blood to satisfy these needs. Hypothesis: The study was undertaken to evaluate whether the effect of combined amlodipine and atenolol therapy on patients with stable angina pectoris and with ST-depression during exercise testing and 48-h ambulatory electrocardiographic monitoring is superior to that of either agent given alone. Methods: Patients with stable angina pectoris and ST depression during exercise and ambulatory monitoring were randomized to receive amlodipine (n = 116) or atenolol (n = 116), or both (n = 119). All patients were also treated with short- and long-acting nitrates. The design was a double-blind, randomized, triple-arm parallel group study with 10 weeks of administration of the test medication. Results: In terms of time to onset of ST depression > I mm, time to onset of angina, total exercise time, maximum achieved workload, and peak intensity of angina, amlodipine and atenolol alone were as effective as their combination. During ambulatory monitoring, atenolol was more effective than amlodipine regarding total time and number of ST-depression episodes, and as effective as the combined drugs. Conclusion: For individual patients with stable angina pectoris, combination of a beta blocker with a calcium antagonist is not necessarily more effective than either drug given alone.

Revue / Journal Title

Clinical cardiology   ISSN 0160-9289   CODEN CLCADC 

Source / Source

2000, vol. 23, n^o10, pp. 763-770 (26 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken, NJ, ETATS-UNIS  (1978) (Revue)

Mots-clés anglais / English Keywords

Angina pectoris ; Amlodipine ; Antianginal agent ; Atenolol ; Drug combination ; Comparative study ; Treatment ; Human ; Dihydropyridine derivatives ; Cardiovascular disease ; Coronary heart disease ; Chemotherapy ;

Mots-clés français / French Keywords

Angine poitrine ; Amlodipine ; Antiangoreux ; Aténolol ; Association médicamenteuse ; Etude comparative ; Traitement ; Homme ; Dihydropyridine dérivé ; Appareil circulatoire pathologie ; Cardiopathie coronaire ; Chimiothérapie ;

Mots-clés espagnols / Spanish Keywords

Angina pectoris ; Amlodipino ; Antianginoso ; Atenolol ; Asociación medicamentosa ; Estudio comparativo ; Tratamiento ; Hombre ; Dihidropiridine derivado ; Aparato circulatorio patología ; Cardiopatía coronaria ; Quimioterapia ;

Localisation / Location

INIST-CNRS, Cote INIST : 19682, 35400009272528.0090