Titre du document / Document title
Biliary excretion and conjugation of diacid angiotensin-converting enzyme inhibitors
Auteur(s) / Author(s)
DRUMMER O. H.
(1) ;
NICOLACI J. ;
IAKOVIDIS D. ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Austin hosp., dep. medicine, Heidelberg Victoria 3084, AUSTRALIE
Résumé / Abstract
We report studies examining the liver clearance and biliary excretion of enalapril, lisinopril, perindopril and ramipril in an isolated perfused rat liver model. In addition we have investigated the formation and biliary excretion of acyl glucuronides of these inhibitors in this model. These studies have also allowed us to examine the influence of structure of these inhibitors of their disposition
Revue / Journal Title
The Journal of pharmacology and experimental therapeutics
ISSN 0022-3565
CODEN JPETAB
Source / Source
1990, vol. 252, n
o3, pp. 1202-1206 (18 ref.)
Langue / Language
Anglais
Editeur / Publisher
American Society for Pharmacology and Experimental Therapeutics, Bethesda, MD, ETATS-UNIS
(1909)
(Revue)
Mots-clés anglais / English Keywords
Enzyme inhibitor ;
Angiotensin converting enzyme ;
Antihypertensive agent ;
Metabolism ;
Liver ;
Rat ;
In vitro ;
Excretion ;
Bile ;
Glucuronidation ;
Structure metabolism relation ;
Rodentia ;
Mammalia ;
Vertebrata ;
Mots-clés français / French Keywords
Enalapril ;
Lisinopril ;
Perindopril ;
Ramipril ;
Inhibiteur enzyme ;
Angiotensin converting enzyme ;
Antihypertenseur ;
Métabolisme ;
Foie ;
Rat ;
In vitro ;
Excrétion ;
Bile ;
Glucuronidation ;
Relation structure métabolisme ;
Métabolisme médicament ;
Rodentia ;
Mammalia ;
Vertebrata ;
Mots-clés espagnols / Spanish Keywords
Inhibidor enzima ;
Angiotensin converting enzyme ;
Antihipertensivo ;
Metabolismo ;
Hígado ;
Rata ;
In vitro ;
Excreción ;
Bilis ;
Glucuronidación ;
Relación estructura metabolismo ;
Rodentia ;
Mammalia ;
Vertebrata ;
Localisation / Location
INIST-CNRS, Cote INIST : 548, 35400000350091.0420
Nº notice refdoc (ud4) : 6871202
