Titre du document / Document title

Chronic infusion of clonidine does not alleviate spontaneous morphine withdrawal symptoms in rats

Auteur(s) / Author(s)

VAN DER LAAN J. W. ; JANSEN VAN'T LAND C. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

National inst. public health environmental protection, lab. medicines medical devices, 3720 BA Bilthoven, PAYS-BAS

Résumé / Abstract

Opiate withdrawal is associated with behavioural symptoms and a sympathetic hyperactivity, the latter being sensitive to clonidine. The central question is whether behavioural symptoms would be also sensitive to clonidine. A rat model was used in which the locomotor activity was measured 24 h a day during the morphine withdrawal phase. Spontaneous withdrawal of morphine reduced strongly the high nocturnal locomotor activity, concomitently decreasing food intake and body weight. Chronic infusion of clonidine (30-120 μg/kg/day) using osmotic minipumps had no erect on the withdrawal symptoms

Revue / Journal Title

Psychopharmacologia   ISSN 0033-3158   CODEN PSYPAG 

Source / Source

1992, vol. 108, n^o3, pp. 283-288 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Berlin, ALLEMAGNE  (1959) (Revue)

Mots-clés anglais / English Keywords

Opiates ; α-Adrenergic receptor agonist ; Mechanism of action ; Chemotherapy ; Treatment efficiency ; Animal ; Subcutaneous administration ; α1-Adrenergic receptor ; α2-Adrenergic receptor ; Morphine ; Drug of abuse ; Withdrawal syndrome ; Rat ; Rodentia ; Mammalia ; Vertebrata ;

Mots-clés français / French Keywords

Opiacés ; Stimulant α-adrénergique ; Mécanisme action ; Chimiothérapie ; Efficacité traitement ; Animal ; Voie souscutanée ; Récepteur α1-adrénergique ; Récepteur α2-adrénergique ; Morphine ; Substance toxicomanogène ; Clonidine ; Sevrage syndrome ; Rat ; Rodentia ; Mammalia ; Vertebrata ;

Mots-clés espagnols / Spanish Keywords

Opiados ; Estimulante α-adrenérgico ; Mecanismo acción ; Quimioterapia ; Eficacia tratamiento ; Animal ; Vía subcutánea ; Receptor α1-adrenérgico ; Receptor α2-adrenérgico ; Sustancia toxicomanógena ; Destete síndrome ; Rata ; Rodentia ; Mammalia ; Vertebrata ;

Localisation / Location

INIST-CNRS, Cote INIST : 1761, 35400002059047.0070