Titre du document / Document title

Sulindac causes regression of rectal polyps in familial adenomatous polyposis

Auteur(s) / Author(s)

LABAYLE D. ⁽¹⁾ ; FISCHER D. ; VIELH P. ; DROUHIN F. ; PARIENTE A. ; BORIES C. ; DUHAMEL O. ; TROUSSET M. ; ATTALI P. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Cent. hosp. Louise Michel, dép. médico-chirurgical maladies appareil digestif, Evry 91014, FRANCE
Inst. Curie, Paris, FRANCE
Cent. hosp. la source, serv. gastroentérologie, Orléans, FRANCE

Résumé / Abstract

In familial adenomatous polyposis, sulindac-induced polyp regression has been reported by several authors. In this study, the goal was to confirm these results by a randomized, placebo-controlled, double-blind crossover study in 10 patients with rectal polyps that had been previously treated by colectomy and ileorectal anastomosis. Patients received sulindac, 300 mg/day, or placebo during two 4-month periods separated by a 1-month wash-out phase. One patient was not compliant and was excluded. With sulindac, the authors observed a complete (6 patients) or almost complete (3 patients) regression of the polyps

Revue / Journal Title

Gastroenterology   ISSN 0016-5085   CODEN GASTAB 

Source / Source

1991, vol. 101, n^o3, pp. 635-639 (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1943) (Revue)

Mots-clés anglais / English Keywords

Polyposis ; Gut ; Rectum ; Tumor ; Human ; Adenomatosis ; Digestive diseases ; Treatment ; Genetic disease ; Polyp ; Non steroidal antiinflammatory agent ; Chemotherapy ;

Mots-clés français / French Keywords

Polypose ; Intestin ; Rectum ; Tumeur ; Homme ; Adénomatose ; Sulindac ; Appareil digestif pathologie ; Traitement ; Maladie héréditaire ; Polype ; Antiinflammatoire non stéroïde ; Chimiothérapie ;

Mots-clés espagnols / Spanish Keywords

Poliposis ; Intestino ; Recto ; Tumor ; Hombre ; Adenomatosis ; Aparato digestivo patología ; Tratamiento ; Enfermedad hereditaria ; Pólipo ; Antiinflamatorio no esteroide ; Quimioterapia ;

Localisation / Location

INIST-CNRS, Cote INIST : 2090, 35400001272252.0050