Titre du document / Document title
Multidrug-resistant phenotype in retinoblastoma correlates with P-glycoprotein expression
Auteur(s) / Author(s)
CHAN H. S. L.
(1) ;
THORNER P. S. ;
HADDAD G. ;
GALLIE B. L. ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Univ. Toronto, dep. pediatrics, div. hematology-oncology, Toronto ON, CANADA
Résumé / Abstract
Chemotherapy plays an important role in therapy for patients with extraocular and metastatic retinoblastoma. The authors used chemotherapy for management of selected patients with uncontrolled intraocular tumors or tumors larger and more posteriorly located than those conventionally treated with local cryotherapy or photocoagulation. Rapid regrowth of some tumors after an initial excellent chemotherapy response led us to investigate the hypothesis that failure of treatment is caused by P-glycoprotein-related multidrug resistance
Revue / Journal Title
Ophthalmology
ISSN 0161-6420
CODEN OPHTDG
Source / Source
1991, vol. 98, n
o9, pp. 1425-1431 (30 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, New York, NY, ETATS-UNIS
(1976)
(Revue)
Mots-clés anglais / English Keywords
Antineoplastic agent ;
Multiple resistance ;
Mechanism of action ;
In vitro ;
Glycoproteins ;
Immunocytochemistry ;
Immunoperoxidase technique ;
Retinoblastoma ;
Malignant tumor ;
Eye disease ;
Retina ;
Cell line ;
Tumor cell ;
Human ;
Animal ;
Mots-clés français / French Keywords
Anticancéreux ;
Résistance multiple ;
Mécanisme action ;
In vitro ;
Glycoprotéine ;
Immunocytochimie ;
Technique immunoperoxydase ;
Rétinoblastome ;
Tumeur maligne ;
Oeil pathologie ;
Rétine ;
Lignée cellulaire ;
Cellule tumorale ;
Homme ;
Animal ;
Glycoprotéine P ;
Mots-clés espagnols / Spanish Keywords
Anticanceroso ;
Resistencia múltiple ;
Mecanismo acción ;
In vitro ;
Glicoproteina ;
Inmunocitoquímica ;
Técnica inmunoperoxidasa ;
Retinoblastoma ;
Tumor maligno ;
Ojo patología ;
Retina ;
Línea celular ;
Célula tumoral ;
Hombre ;
Animal ;
Localisation / Location
INIST-CNRS, Cote INIST : 18914, 35400001045849.0190
Nº notice refdoc (ud4) : 4996640
