Titre du document / Document title
Evaluation of methylene blue and triple therapy for eradication of Helicobacter pylori infection in the nude mouse model
Auteur(s) / Author(s)
KARITA M.
(1) ;
TADA M.
(1) ;
OKITA K.
(1) ;
TSUDA M. ;
NAKAZAWA T. ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Yamaguchi univ. school medicine, I dep. internal medicine, Ube-shi Yamaguchi-ken 755, JAPON
Résumé / Abstract
Objective: To determine how far Helicobacter pylori infection can be eradicated with methylene blue and triple therapy (amoxicillin, metronidazole, bismuth subnitrate), using a nude mouse model. Methods: Four weeks after inoculation of H. pylori into the stomach, two groups of nude mice were administered methylene blue or triple therapy via the stomach for 1 week. A control group of nude mice was given culture fluid alone after the inoculation. The number of H. pylori and histological changes in the stomach were determined weekly for 5 weeks, starting from the completion of drug administration. Results: In the methylene blue treatment group, the concentration of H. pylori was significantly reduced for 1-3 weeks after treatment compared with the control group
Revue / Journal Title
European journal of gastroenterology & hepatology
ISSN 0954-691X
Source / Source
Congrès
International symposium on Helicobacter pylori and its diseases N
o5, Tokyo
, JAPON
(04/04/1992)
1993, vol. 5, SUP1 (6 ref.), pp. S79-S83
Langue / Language
Anglais
Editeur / Publisher
Lippincott Williams & Wilkins, Hagerstown, MD, ETATS-UNIS
(1989)
(Revue)
Mots-clés anglais / English Keywords
Campylobacter infection ;
Helicobacter pylori ;
Stomach ;
Treatment ;
Animal ;
Animal model ;
Experimental disease ;
Chemotherapy ;
Mouse ;
Antibiotic ;
Bacteriosis ;
Infection ;
Gastric disease ;
Spirillaceae ;
Spirillales ;
Bacteria ;
Digestive diseases ;
Rodentia ;
Mammalia ;
Vertebrata ;
Mots-clés français / French Keywords
Campylobactériose ;
Helicobacter pylori ;
Estomac ;
Traitement ;
Animal ;
Modèle animal ;
Pathologie expérimentale ;
Chimiothérapie ;
Souris ;
Antibiotique ;
Bactériose ;
Infection ;
Estomac pathologie ;
Spirillaceae ;
Spirillales ;
Bactérie ;
Appareil digestif pathologie ;
Rodentia ;
Mammalia ;
Vertebrata ;
Mots-clés espagnols / Spanish Keywords
Campilobacteriosis ;
Helicobacter pylori ;
Estómago ;
Tratamiento ;
Animal ;
Modelo animal ;
Patología experimental ;
Quimioterapia ;
Ratón ;
Antibiótico ;
Bacteriosis ;
Infección ;
Estómago patología ;
Spirillaceae ;
Spirillales ;
Bacteria ;
Aparato digestivo patología ;
Rodentia ;
Mammalia ;
Vertebrata ;
Localisation / Location
INIST-CNRS, Cote INIST : 22107, 35400003547115.0140
Nº notice refdoc (ud4) : 4893514
