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Titre du document / Document title

An evaluation of the influence of reproductive factors on the risk of metastases from uveal melanoma. Discussion

Auteur(s) / Author(s)

EGAN K. M. (1) ; WALSH S. M. (1) ; SEDDON J. M. (1) ; GRAGOUDAS E. S. (1) ; AUGSBURGER J. J. (Commentateur) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Massachusetts eye ear infirmary, retina serv., Boston MA, ETATS-UNIS

Résumé / Abstract

Background: There is a paucity of data concerning the possible role played by hormonal factors in the risk of metastases from intraocular melanomas. Methods: The authors studied the influence of post-diagnosis pregnancy and oral contraceptive use in a group of women of reproductive age (45 or younger) who were treated for uveal melanoma by proton beam irradiation. A baseline reproductive history had been collected before irradiation for all women, and interim reproductive data were collected by mailed questionnaire. Results: In this age group, the overall rate of metastasis among women was similar to that of men treated during the same interval (adjusted rate ratio:1.28; 95% confidence interval:0.62-2.67). A total of 24 full-term pregnancies were reported among the 139 women still menstruating at diagnosis

Revue / Journal Title

Ophthalmology    ISSN  0161-6420   CODEN OPHTDG 

Source / Source

1993, vol. 100, no8, pp. 1160-1166 (39 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1976) (Revue)

Mots-clés anglais / English Keywords

Malignant melanoma

;

Metastasis

;

Uvea

;

Young adult

;

Pregnancy

;

Oral administration

;

Female

;

Contraceptive

;

Human

;

Malignant tumor

;

Risk factor

;

Uvea disease

;

Mots-clés français / French Keywords

Mélanome malin

;

Métastase

;

Uvée

;

Adulte jeune

;

Gestation

;

Voie orale

;

Femelle

;

Contraceptif

;

Homme

;

Tumeur maligne

;

Facteur risque

;

Uvée pathologie

;

Mots-clés espagnols / Spanish Keywords

Melanoma maligno

;

Metástasis

;

Uvea

;

Adulto joven

;

Gestación

;

Vía oral

;

Hembra

;

Anticonceptivo

;

Hombre

;

Tumor maligno

;

Factor riesgo

;

Localisation / Location

INIST-CNRS, Cote INIST : 18914, 35400003550929.0090

Nº notice refdoc (ud4) : 4880180



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