Titre du document / Document title

The urinary light-chain ladder pattern : a product of improved methodology that may complicate the recognition of Bence Jones proteinuria

Auteur(s) / Author(s)

BAILEY E. M. ⁽¹⁾ ; MCDERMOTT T. J. ; BLOCH K. J. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Harvard medical school, dep. pathology, Boston MA, ETATS-UNIS

Résumé / Abstract

Objective.-To describe the recently reported urinary light-chain «ladder» pattern and to indicate that this phenomenon, which may give rise to confusion with Bence Jones protein (BJP), may be observed during routine examination of 50-fold concentrated urine samples tested by highresolution agarose gel electrophoresis and immunofixation. Methods.-Urine samples that were usually submitted for examination for the presence of BJP were concentrated 50-fold. Concentrated urine samples were subjected to immunoelectrophoresis and agarose gel electrophoresis. Samples that failed to show a BJP on immunoelectrophoresis but which did show a faint banding pattern in the stained agarose gel were subjected to immunofixation

Revue / Journal Title

Archives of pathology & laboratory medicine   ISSN 0363-0153   CODEN APLMAS 

Source / Source

1993, vol. 117, n^o7, pp. 707-710 (15 ref.)

Langue / Language

Anglais

Editeur / Publisher

College of American Pathologists, Northbrook, IL, ETATS-UNIS  (1976) (Revue)

Mots-clés anglais / English Keywords

Proteinuria ; Bence Jones protein ; Differential diagnostic ; Human ; Gel electrophoresis ; Immunoelectrophoresis ; Image interpretation ; light-Peptide chain ; Urine ;

Mots-clés français / French Keywords

Protéinurie ; Protéine Bence Jones ; Diagnostic différentiel ; Homme ; Electrophorèse gel ; Immunoélectrophorèse ; Interprétation image ; Chaîne peptidique légère ; Urine ;

Mots-clés espagnols / Spanish Keywords

Proteinuria ; Proteína Bence Jones ; Diagnóstico diferencial ; Hombre ; Electroforesis gel ; Inmunoelectroforesis ; Interpretación imágen ; Cadena peptídica ligera ; Orina ;

Localisation / Location

INIST-CNRS, Cote INIST : 2050, 35400003507218.0090