Titre du document / Document title

Induction of HIV-1-neutralising and syncytium-inhibiting antibodies in uninfected recipients of HIV-1_IIIB rgp120 subunit vaccine

Auteur(s) / Author(s)

SCHWARTZ D. H. ⁽¹⁾ ; GORSE G. ; CLEMENTS M. L. ⁽¹⁾ ; BELSHE R. ; IZU A. ; DULIEGE A.-M. ; BERMAN P. ; TWADDELL T. ; STABLEIN D. ; SPOSTO R. ; SILICIANO R. ; MATTHEWS T. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Johns Hopkins univ. school hyg. public health, cent. immunization res., Baltimore MD 21205-1901, ETATS-UNIS

Résumé / Abstract

A recombinant human immunodeficiencyvirus 1 IIIB (HIV-1_IIIB) gp120 subunit vaccine (IIIB-rgp120/HIV-1, Genentech) was tested for safety and immunogenicity in a randomised, double-blind, placebo-controlled phase-I trial. HIV-1-seronegative adult volunteers received three 100 μg or 300 μg doses of IIIB-rgp120/HIV-1 in alum adjuvant (10 vaccinees in each group), or alum adjuvant alone (8 vaccinees), at 0, 4, and 32 weeks by intramuscular injection. The three injections were well tolerated in both vaccine groups. Antibodies that neutralised homologous HIV-1_IIIB were induced in 9 of 10 recipients after three 300 μg doses, and 6 of these 9 sera also neutralised heterologous HIV-1_SF2

Revue / Journal Title

Lancet   ISSN 0140-6736   CODEN LANCAO 

Source / Source

1993, vol. 342, n^o8863, pp. 69-73 (13 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lancet, London, ROYAUME-UNI  (1823) (Revue)

Mots-clés anglais / English Keywords

Result ; Treatment ; Human ; Phase I trial ; Vaccine ; Volunteer ; Virus envelope ; Recombinant protein ; Human immunodeficiency virus ; Lentivirinae ; Retroviridae ; Virus ;

Mots-clés français / French Keywords

Résultat ; Traitement ; Homme ; Essai clinique phase I ; Vaccin ; Volontaire ; Enveloppe virus ; Protéine recombinante ; Virus immunodéficience humaine ; Lentivirinae ; Retroviridae ; Virus ;

Mots-clés espagnols / Spanish Keywords

Resultado ; Tratamiento ; Hombre ; Ensayo clínico fase I ; Vacuna ; Voluntario ; Cubierta virus ; Proteína recombinante ; Human immunodeficiency virus ; Lentivirinae ; Retroviridae ; Virus ;

Localisation / Location

INIST-CNRS, Cote INIST : 5004, 35400003456093.0070