Titre du document / Document title

Influence of labetalol on cocaine-induced coronary vasoconstriction in humans

Auteur(s) / Author(s)

BOEHRER J. D. ; MOLITERNO D. J. ; WILLARD J. E. ; HILLIS L. D. ; LANGE R. A. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Univ. Texas Southwestern medical cent., dep. internal medicine, Dallas TX 75235, ETATS-UNIS

Résumé / Abstract

PURPOSE: Although labetalol is sometimes given to patients with cocaine-associated chest pain, its influence on cocaine-induced coronary vasoconstriction is unknown. PATIENTS AND METHODS: In 15 patients (7 men, 8 women, aged 40 to 79 years) undergoing catherization for chest pain, heart rate, mean arterial pressure, and coronary arterial area (by computer-assisted quantitative angiography) were measured (1) at baseline, (2) 15 minutes after intranasal cocaine, 2 mg/kg, ten (3) 5 minutes after intravenous saline (n=6) or labetalol, 0.25 mg/kg (n=9)

Revue / Journal Title

The American journal of medicine   ISSN 0002-9343   CODEN AJMEAZ 

Source / Source

1993, vol. 94, n^o6, pp. 608-610 (7 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1946) (Revue)

Mots-clés anglais / English Keywords

Human ; Treatment ; Cardiovascular disease ; Coronary heart disease ; Vasoconstriction ; Cocaine ; Toxicity ; Beta blocking agent ;

Mots-clés français / French Keywords

Homme ; Traitement ; Appareil circulatoire pathologie ; Cardiopathie coronaire ; Vasoconstriction ; Cocaïne ; Toxicité ; Labétalol ; Bloquant β-adrénergique ;

Mots-clés espagnols / Spanish Keywords

Hombre ; Tratamiento ; Aparato circulatorio patología ; Cardiopatía coronaria ; Vasoconstricción ; Cocaína ; Toxicidad ; Bloqueador β-adrenérgico ;

Localisation / Location

INIST-CNRS, Cote INIST : 4562, 35400003429827.0080