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Titre du document / Document title

Transdermal absorption of steroids

Auteur(s) / Author(s)

KNUTSON K. (1) ; HARRISON D. J. (1) ; PERSHING L. K. ; GOATES C. Y. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Coll. pharmacy, dep. pharmaceutics/CCCD, Salt Lake City UT, ETATS-UNIS

Résumé / Abstract

The transport mechanisms of selected steroids in the presence of a series of aqueous ethanol solutions have been probed in vitro using hairless mouse and human tissue, as well as in vivo using the unique human skin sandwich flap model. Permeation and biophysical studies have also been performed under similar conditions in order to elucidate the biophysical alterations in hairless mouse and human stratum corneum induced by the vehicle solutions that contribute to the percutaneous transport mechanisms of steroids. Progesterone, estradiol and hydrocortisone transport across hairless mouse skin under the same conditions was examined to explore the effects of permeant properties. Steroid uptake and in vitro permeability coefficients across both skin species decreased with decreasing steroid lipophilicity

Revue / Journal Title

Journal of controlled release    ISSN  0168-3659   CODEN JCREEC 

Source / Source

Congrès
European symposium on controlled drug delivery No2, Noordwijk aan Zee , PAYS-BAS (01/04/1992)
1993, vol. 24, no 1-3 (51 ref.), pp. 95-108

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1984) (Revue)

Mots-clés anglais / English Keywords

Steroid hormone

;

Drug

;

Aqueous solution

;

Ethanol

;

Absorption

;

Skin

;

Human

;

Mouse

;

Animal

;

In vitro

;

Percutaneous route

;

Comparative study

;

Permeability

;

Progesterone

;

Cortisol

;

Rodentia

;

Mammalia

;

Vertebrata

;

Mots-clés français / French Keywords

Hormone stéroïde

;

Médicament

;

Solution aqueuse

;

Ethanol

;

Absorption

;

Peau

;

Homme

;

Souris

;

Animal

;

In vitro

;

Voie percutanée

;

Etude comparative

;

Perméabilité

;

Progestérone

;

Estradiol

;

Hydrocortisone

;

Rodentia

;

Mammalia

;

Vertebrata

;

Mots-clés espagnols / Spanish Keywords

Hormona esteroide

;

Medicamento

;

Solución acuosa

;

Etanol

;

Absorción

;

Piel

;

Hombre

;

Ratón

;

Animal

;

In vitro

;

Vía percutánea

;

Estudio comparativo

;

Permeabilidad

;

Progesterona

;

Hidrocortisona

;

Rodentia

;

Mammalia

;

Vertebrata

;

Localisation / Location

INIST-CNRS, Cote INIST : 20704, 35400003375830.0070

Nº notice refdoc (ud4) : 4804926



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