Titre du document / Document title

Randomised controlled trial of nasal ventilation in acute ventilatory failure due to chronic obstructive airways disease

Auteur(s) / Author(s)

BOTT J. ⁽¹⁾ ; CARROLL M. P. ; CONWAY J. H. ; KEILTY S. E. J. ⁽¹⁾ ; WARD E. M. ; BROWN A. M. ; PAUL E. A. ; ELLIOTT M. W. ⁽¹⁾ ; GODFREY R. C. ; WEDZICHA J. A. ; MOXHAM J. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ King's coll. school medicine dentistry, London, ROYAUME-UNI

Résumé / Abstract

Acute exacerbations of chronic obstructive airways disease (COAD) are a common cause of admission to hospital, and have a high mortality. Nasal intermittent positive pressure ventilation (NIPPV) has been used successfully in patients with respiratory failure due to neuromuscular and skeletal disorders, but the outcome of treatment in patients with COAD is less well known. We carried out a prospective randomised controlled trial of conventional treatment versus conventional treatment plus NIPPV, in 60 patients with acute ventilatoryfailureduetoexacerbationsofCOAD. For the NIPPV group there was a rise in pH, compared with a fall in the controls (mean difference of change between the groups 0-046 [95% Cl 0.06-0.02, p<0.001]), AND A LARGER FALL IN PACO₂ (mean difference in change between the groups 1.2 kPa [95% Cl 0.45 to 2.03, p<0.01])

Revue / Journal Title

Lancet   ISSN 0140-6736   CODEN LANCAO 

Source / Source

1993, vol. 341, n^o8860, pp. 1555-1557 (9 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lancet, London, ROYAUME-UNI  (1823) (Revue)

Mots-clés anglais / English Keywords

Respiratory intensive care ; Result ; Treatment ; Human ; Comparative study ; Respiratory failure ; Acute ; Positive pressure ; Intermittent ; Assisted ventilation ; Treatment efficiency ; Respiratory disease ; Obstructive pulmonary disease ; Resuscitation ;

Mots-clés français / French Keywords

Réanimation respiratoire ; Résultat ; Traitement ; Homme ; Etude comparative ; Insuffisance respiratoire ; Aigu ; Pression positive ; Intermittent ; Ventilation assistée ; Efficacité traitement ; Voie nasale ; Appareil respiratoire pathologie ; Bronchopneumopathie obstructive ; Réanimation ;

Mots-clés espagnols / Spanish Keywords

Reanimación respiratoria ; Resultado ; Tratamiento ; Hombre ; Estudio comparativo ; Insuficiencia respiratoria ; Agudo ; Presión positiva ; Intermitente ; Ventilación asistida ; Eficacia tratamiento ; Aparato respiratorio patología ; Enfermedad pulmonar obstructiva crónica ; Reanimación ;

Localisation / Location

INIST-CNRS, Cote INIST : 5004, 35400003417533.0030