Titre du document / Document title

Electrochemical study of the oxidation of carbidopa and its determination using liquid chromatography with electrochemical detection

Auteur(s) / Author(s)

TÖMPE P. ; HALBAUER A. N. ; LADANYI L. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

EGIS Pharmaceuticals, 1475 Budapest, HONGRIE

Résumé / Abstract

The electrochemical oxidation of carbidopa [(S)-(-)-2-(3,4-dihydroxybenzyl)-2-hydrazinopropionic acid monohydrate] was studied by linear sweep voltammetry, cyclic voltammetry, microcoulometry and preparative electrolysis. An ECCE mechanism with two-electron transfer, followed by two chemical reactions (decarboxylation and hydrolysis), were found, giving carbon dioxide, hydrazine and 3,4-dihydroxyphenylacetone. The final electrochemical step may be a reversible two-electron oxidation process which gives the o-quinoidal analogue of the latter. An analogous oxidation mechanism was found when carbidopa was oxidized with HBrCl₂ in hydroxychloric acid

Revue / Journal Title

Analytica chimica acta   ISSN 0003-2670   CODEN ACACAM 

Source / Source

Congrès
ESEAC'92. European conference on electroanalysis N^o4, Noorwijkerhout , PAYS-BAS (31/05/1992)
1993, vol. 273, n^o1-2, pp. 391-398 (11 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1947) (Revue)

Mots-clés anglais / English Keywords

Electrochemical reaction ; Oxidation ; Chemical analysis ; Liquid chromatography ; Voltammetry ; Drug ; Phenol ; Carboxylic acid ;

Mots-clés français / French Keywords

Réaction électrochimique ; Oxydation ; Carbidopa ; Analyse chimique ; Chromatographie phase liquide ; Voltammétrie ; Médicament ; Phénol ; Acide carboxylique ;

Mots-clés espagnols / Spanish Keywords

Reacción electroquímica ; Oxidación ; Análisis químico ; Cromatografía fase líquida ; Voltametría ; Medicamento ; Fenol ; Acido carboxílico ;

Localisation / Location

INIST-CNRS, Cote INIST : 3950, 35400003876647.0440