Titre du document / Document title

Vascular pericytes not only regulate growth, but also preserve prostacyclin-producing ability and protect against lipid peroxide-induced injury of co-cultured endothelial cells

Auteur(s) / Author(s)

YAMAGISHI S.-I. ⁽¹⁾ ; KOBAYASHI K.-I. ; YAMAMOTO H. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Kanazawa univ., school medicine, dep. biochemistry, Kanazawa 920, JAPON

Résumé / Abstract

Interactions between vascular pericytes and endothelial cells were studied. Bovine retinal pericytes were found not only to inhibit growth of co-cultured human umbilical endothelial cells, but also to cause significant stimulation of prostacyclin production in the endothelial cells, both of which were achieved by close apposition of the two cell types. Substitution of a fibroblast feeder layer for the pericytes gave no change. Moreover, pericytes could confer protection against lipid peroxide-induced injury of endothelial cells, as determined by the release of [³H]-2-deoxy-D-glucose from radiolabeled endothelial cells

Revue / Journal Title

Biochemical and biophysical research communications   ISSN 0006-291X   CODEN BBRCA9 

Source / Source

1993, vol. 190, n^o2, pp. 418-425 (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, San Diego, CA, ETATS-UNIS  (1959) (Revue)

Mots-clés anglais / English Keywords

Endothelial cell ; Blood vessel ; Pericyte ; Retina ; Cell cooperation ; Regulation(control) ; Cell proliferation ; Biosynthesis ; Prostaglandin I2 ; Protection ; Peroxidation ; Mixed cell culture ; Bovine ; Artiodactyla ; Ungulata ; Mammalia ; Vertebrata ; Lipids ;

Mots-clés français / French Keywords

Cellule endothéliale ; Vaisseau sanguin ; Péricyte ; Rétine ; Coopération cellulaire ; Régulation ; Multiplication cellulaire ; Biosynthèse ; Prostaglandine I2 ; Protection ; Peroxydation ; Culture cellulaire mixte ; Bovin ; Artiodactyla ; Ungulata ; Mammalia ; Vertebrata ; Lipide ;

Mots-clés espagnols / Spanish Keywords

Célula endotelial ; Vaso sanguíneo ; Pericito ; Retina ; Cooperación celular ; Regulación ; Multiplicación celular ; Biosíntesis ; Prostaglandina I2 ; Protección ; Peroxidación ; Cultivo celular mixto ; Bovino ; Artiodactyla ; Ungulata ; Mammalia ; Vertebrata ; Lípido ;

Localisation / Location

INIST-CNRS, Cote INIST : 8252, 35400003845527.0160