Titre du document / Document title

Risk factors for colorectal cancer in patients with ulcerative colitis : a case-control study

Auteur(s) / Author(s)

PINCZOWSKI D. ; EKBOM A. ; BARON J. ; YUEN J. ; ADAMI H.-O. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Univ. hosp., cancer epidemiology unit, 751 85 Uppsala, SUEDE

Résumé / Abstract

Background/Aims: The risk of colorectal cancer increases in patients with ulcerative colitis, most markedly among young patients and/or those with extensive disease at onset. However, it is unknown whether individual risk can be predicted more precisely and whether cancer risk can be reduced by long-term treatment with sulfasalazine. Methods: In a population-based cohort of 3112 patients with ulcerative colitis, we compared 102 cases of colorectal cancer and 196 matched controls without cancer. Hospital records were used to abstract information on pharmacological therapy, disease activity, and extraintestinal manifestations. The relative risk (RR) of cancer was estimated by conditional logistic regression

Revue / Journal Title

Gastroenterology   ISSN 0016-5085   CODEN GASTAB 

Source / Source

1994, vol. 107, n^o1, pp. 117-120 (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1943) (Revue)

Mots-clés anglais / English Keywords

Ulcerative colitis ; Malignant tumor ; Colon ; Rectum ; Chemotherapy ; Risk factor ; Complication ; Prevention ; Human ; Sulfonamide ; Digestive diseases ; Intestinal disease ; Inflammatory disease ; Anorectal disease ; Colonic disease ;

Mots-clés français / French Keywords

Rectocolite ulcérohémorragique ; Tumeur maligne ; Côlon ; Rectum ; Chimiothérapie ; Facteur risque ; Complication ; Prévention ; Homme ; Sulfasalazine ; Sulfonamide ; Appareil digestif pathologie ; Intestin pathologie ; Maladie inflammatoire ; Anorectale pathologie ; Côlon pathologie ;

Mots-clés espagnols / Spanish Keywords

Rectocolitis ulcerohemorrágica ; Tumor maligno ; Colón ; Recto ; Quimioterapia ; Factor riesgo ; Complicación ; Prevención ; Hombre ; Sulfonamida ; Aparato digestivo patología ; Intestino patología ; Enfermedad inflamatoria ; Anorrectal patología ; Colón patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 2090, 35400004708534.0150