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Titre du document / Document title

Growth promoting peptides in osteoarthritis and diffuse idiopathic skeletal hyperostosis : insulin, insulin-like growth factor-I, growth hormone

Auteur(s) / Author(s)

DENKO C. W. ; BOJA B. ; MOSKOWITZ R. W. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Case Western Reserve univ., school medicine, dep. medicine, Cleveland OH, ETATS-UNIS

Résumé / Abstract

Objective. To investigate growth factors influencing bone and cartilage in patients with diffuse idiopathic skeletal hyperostosis (DISH). Methods. Standard radioimmunoassays (INCSTAR, Stillwater, MN) quantified serum levels of insulin, insulin-like growth factor-I (IGF-I) and growth hormone (GH) in patients with DISH, in patients with osteoarthritis (OA) and in controls. Patients with DISH with comorbidity with obesity, hypertension, diabetes and coronary artery disease, also were studied. Results. Patients with DISH demonstrated normal IGF-I levels; patients with OA had reduced IGF-I levels. Subjects with DISH or OA had elevated insulin and GH values. Patients with DISH with comorbidity had changes in growth factors similar to those found in patients with DISH only

Revue / Journal Title

Journal of rheumatology    ISSN  0315-162X   CODEN JRHUA9 

Source / Source

1994, vol. 21, no9, pp. 1725-1730 (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Journal of Rheumatology Publishing, Toronto, ON, CANADA  (1974) (Revue)

Mots-clés anglais / English Keywords

Ankylosing hyperostosis

;

Osteoarthritis

;

Human

;

STH

;

Insulin

;

Somatomedin C

;

Exploration

;

Serum

;

Quantitative analysis

;

Diseases of the osteoarticular system

;

Disease of the spine

;

Degenerative disease

;

Arthropathy

;

Adenohypophyseal hormone

;

Protein hormone

;

Pancreatic hormone

;

Growth factor

;

Polypeptide

;

Cytokine

;

Mots-clés français / French Keywords

Hyperostose ankylosante vertébrale

;

Arthrose

;

Homme

;

STH

;

Insuline

;

Somatomédine C

;

Exploration

;

Sérum

;

Analyse quantitative

;

Système ostéoarticulaire pathologie

;

Rachis pathologie

;

Maladie dégénérative

;

Arthropathie

;

Hormone adénohypophysaire

;

Hormone protéine

;

Hormone pancréatique

;

Facteur croissance

;

Polypeptide

;

Cytokine

;

Mots-clés espagnols / Spanish Keywords

Hiperóstosis anquilosante vertebral senil

;

Artrosis

;

Hombre

;

STH

;

Insulina

;

Somatomedina C

;

Exploración

;

Suero

;

Análisis cuantitativo

;

Sistema osteoarticular patología

;

Raquis patología

;

Enfermedad degenerativa

;

Artropatía

;

Hormona adenohipofisaria

;

Hormona proteina

;

Hormona pancreática

;

Factor crecimiento

;

Polipéptido

;

Citoquina

;

Localisation / Location

INIST-CNRS, Cote INIST : 16024, 35400004146594.0270

Nº notice refdoc (ud4) : 4204126



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