Titre du document / Document title

Treatment of glucocorticoid-resistant or relapsing Takayasu arteritis with methotrexate

Auteur(s) / Author(s)

HOFFMAN G. S. ; LEAVITT R. Y. ; KERR G. S. ; ROTTEM M. ; SNELLER M. C. ; FAUCI A. S. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

NIH, national inst. allergy infectious diseases, Bethesda MD, ETATS-UNIS

Résumé / Abstract

Objective. To identify the role of methotrexate (MTX) in the treatment of persistent or recurrent Takayasu arteritis that is refractory to treatment with glucocorticoids (GC) alone. Methods. An open-label pilot study of weekly low-dose MTX+GC treatment was performed. Outcome was evaluated according to clinical characteristics, laboratory abnormalities, findings on routinely performed angiogpaphic studies, and ability to withdraw GC and MTX therapy. Eighteen patients entered the study; 2 dropped out, and 16 were followed up for a mean period of 2.8 years (range 1.3-4.8 years). Results. Weekly administration of MTX (mean stable dose of 17.1 mg) and GC resulted in remissions in 13 of 16 patients (81%)

Revue / Journal Title

Arthritis and rheumatism   ISSN 0004-3591   CODEN ARHEAW 

Source / Source

1994, vol. 37, n^o4, pp. 578-582 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Hoboken , NJ, ETATS-UNIS  (1958) (Revue)

Mots-clés anglais / English Keywords

Takayashu arteritis ; Human ; Treatment ; Drug combination ; Chemotherapy ; Glucocorticoid ; Administration schedule ; Weekly ; Oral administration ; Follow up study ; Corticosteroid ; Antifolate ; Cardiovascular disease ; Vascular disease ; Vasculitis ; Systemic disease ; Immunomodulator ;

Mots-clés français / French Keywords

Artérite oblitérante Takayashu ; Homme ; Traitement ; Association médicamenteuse ; Chimiothérapie ; Glucocorticoïde ; Méthotrexate ; Rythme administration ; Hebdomadaire ; Voie orale ; Etude longitudinale ; Corticostéroïde ; Antifolate ; Appareil circulatoire pathologie ; Vaisseau sanguin pathologie ; Vascularite ; Maladie système ; Immunomodulateur ;

Mots-clés espagnols / Spanish Keywords

Arteritis obliterante Takayashu ; Hombre ; Tratamiento ; Asociación medicamentosa ; Quimioterapia ; Glucocorticoide ; Ritmo administración ; Semanal ; Vía oral ; Estudio longitudinal ; Corticoesteroide ; Antifolato ; Aparato circulatorio patología ; Vaso sanguíneo patología ; Vasculitis ; Enfermedad sistémica ; Inmunomodulador ;

Localisation / Location

INIST-CNRS, Cote INIST : 8711, 35400004566312.0180