Titre du document / Document title

³¹P-{¹H} nuclear Overhauser effects of phosphorus-containing metabolites in chemical exchange between free and macromolecular bound states

Auteur(s) / Author(s)

WANG S. X. ; CAINES G. H. ; SCHLEICH T. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Univ. California, dep. chemistry biochemistry, Santa Cruz CA 95064, ETATS-UNIS

Résumé / Abstract

The formalism for the steady-state ³¹P-{¹H} nuclear Overhauser effect was extended to include the effects of nuclear-spin magnetization transfer between two sites, F↔B, representing free and macromolecular bound ligand states, respectively, such as might be encountered in viva. Theoretical interpretations of the NOE based on models excluding the effects of phosphorus-metabolite exchange between free and macromolecular bound ligand states are potentially inadequate for tissue systems and may not properly represent the experimentally measured NOE. Analytical expressions were derived describing the behavior of the steady-state transferred heteronuclear NOE assuming broadband proton saturation

Revue / Journal Title

Journal of magnetic resonance. Series B   ISSN 1064-1866 

Source / Source

1993, vol. 102, n^o1, pp. 47-53 (22 ref.)

Langue / Language

Anglais

Editeur / Publisher

Academic Press, Orlando, FL, ETATS-UNIS  (1993-1996) (Revue)

Mots-clés anglais / English Keywords

NMR spectrometry ; Metabolite ; Phosphorus ; Overhauser effect ; Chemical exchange ; Bound state ; Relaxation time ; Technique ;

Mots-clés français / French Keywords

Spectrométrie RMN ; Métabolite ; Phosphore ; Effet Overhauser ; Echange chimique ; Etat lié ; Temps relaxation ; Technique ;

Mots-clés espagnols / Spanish Keywords

Espectrometría RMN ; Metabolito ; Fósforo ; Efecto Overhauser ; Intercambio químico ; Estado ligado ; Tiempo relajación ; Técnica ;

Localisation / Location

INIST-CNRS, Cote INIST : 14241 B, 35400004742475.0060