Titre du document / Document title

Is ursodeoxycholic acid an effective therapy for total parenteral nutrition-related liver disease ?

Auteur(s) / Author(s)

BEAU P. ; LABAT-LABOURDETTE J. ; INGRAND P. ; BEAUCHANT M. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Univ. hosp., gastroenterology nutritional support unit, 86021 Poitiers, FRANCE
Univ. hosp., biostatistics unit, Poitiers, FRANCE

Résumé / Abstract

Cholestasis is the predominant complication in patients with total parenteral nutrition-related liver disease. Ursodeoxycholic acid has been reported to be beneficial for patients with various chronic cholestatic liver diseases. The aim of this prospective study was to determine the effects of short-term administration of ursodeoxycholic acid in nine patients (mean age 54 years) treated with home total parenteral nutrition (31±2 (mean±SEM) kcal/kg per day) for 13.9±5.2 months for short bowel syndrome; all presented biological evidence of hepatic cholestasis (mean alkaline phosphatase activity 5.2 times the upper limit of the normal) which appeared during nutrition; there was no cause of hepatic dysfunction other than total parenteral nutrition

Revue / Journal Title

Journal of hepatology   ISSN 0168-8278   CODEN JOHEEC 

Source / Source

1994, vol. 20, n^o2, pp. 240-244 (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Oxford, ROYAUME-UNI  (1985) (Revue)

Mots-clés anglais / English Keywords

Nutrition ; Parenteral administration ; Human ; Cholostasis ; Complication ; Treatment ; Chemotherapy ; Short term ; Digestive diseases ; Biliary tract disease ; Hepatic disease ;

Mots-clés français / French Keywords

Nutrition ; Voie parentérale ; Homme ; Cholostase ; Complication ; Traitement ; Chimiothérapie ; Ursodésoxycholique acide ; Court terme ; Appareil digestif pathologie ; Voie biliaire pathologie ; Foie pathologie ;

Mots-clés espagnols / Spanish Keywords

Nutrición ; Vía parenteral ; Hombre ; Colostasis ; Complicación ; Tratamiento ; Quimioterapia ; Corto plazo ; Aparato digestivo patología ; Vía biliar patología ; Hígado patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 20706, 35400004898921.0130