Titre du document / Document title

Interactions between insulin and sodium homeostasis in essential hypertension

Auteur(s) / Author(s)

SEMPLICINI A. ; CEOLOTTO G. ; MASSIMINO M. ; VALLE R. ; SERENA L. ; DE TONI R. ; PESSINA A. C. ; DAL PALU C. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Univ. Padua, clin. medica I, 35126 Padova, ITALIE

Résumé / Abstract

It has been proposed, therefore, that hyperinsulinemia may favor the development of hypertension through sodium retention, sympathetic nervous system activation, and vascular hypertrophy. In insulin-resistant hypertensive subjects, insulin infusion during euglycemic clamp promotes a transient sodium retention by stimulating proximal tubular Na⁺ reabsorption, but chronic hypertension usually is not associated with extracellular fluid and plasma volume expansion. In essential hypertensive subjects, intracellular potassium is decreased and intracellular sodium increased, which is consistent with insulin resistance. The latter is also associated with high red blood cell Li⁺/Na⁺ exchange, and chronic insulin treatment in insulin-dependent diabetics induces a slight increase in Li⁺/Na⁺ CT

Revue / Journal Title

The American journal of the medical sciences   ISSN 0002-9629   CODEN AJMSA9 

Source / Source

1994, vol. 307, pp. S43-S46, SUP1 (23 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott, Hagerstown, MD, ETATS-UNIS  (1827) (Revue)

Mots-clés anglais / English Keywords

Hypertension ; Exploration ; Human ; Insulin ; Sodium ; Homeostasis ; Cardiovascular disease ;

Mots-clés français / French Keywords

Hypertension artérielle ; Exploration ; Homme ; Insuline ; Sodium ; Homéostasie ; Appareil circulatoire pathologie ;

Mots-clés espagnols / Spanish Keywords

Hipertensión arterial ; Exploración ; Hombre ; Insulina ; Sodio ; Homeostasis ; Aparato circulatorio patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 2054, 35400002506658.0070