Titre du document / Document title

Polycitone A and polycitrins A and B : new alkaloids from the marine ascidian Polycitor sp.

Auteur(s) / Author(s)

RUDI A. ; GOLDBERG I. ; STEIN Z. ; FROLOW F. ; YEHUDA BENAYAHU ; SCHLEYER M. ; KASHMAN Y. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Tel Aviv univ., school chemistry, Ramat Aviv 69978, ISRAEL

Résumé / Abstract

Three novel compound polycitone A (1a) and polycitrins A and B (2 and 3) were isolated from the marine ascidian Polycitor sp. The structures of compounds 1a, 2, and 3 were established mainly on the basis of NMR spectroscopic data and, in the case of 1a, also by single-crystal X-ray diffraction analysis. The crystallographic analysis was performed on 1b, the penta-O-methyl derivative of 1a, both compound yielding poorly diffracting crystals of highly anisotropic shape. It required, in view of the dominating heavy-atom content of 1b, diffraction measurements with an intense rotating-anode X-ray source. Polycitone A and polycitrins A and B represent the first examples of two new classes of marine products which might biogenetically be close to the lamellarins. The penta-O-methyl derivatives 1b, was found to inhibit the growth of SV40 transformed fibroblast cells in a concentration of 10 μg/mL

Revue / Journal Title

Journal of organic chemistry   ISSN 0022-3263   CODEN JOCEAH 

Source / Source

1994, vol. 59, n^o5, pp. 999-1003 (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Chemical Society, Washington, DC, ETATS-UNIS  (1936) (Revue)

Mots-clés anglais / English Keywords

Isolation ; Molecular structure ; NMR spectrum ; Alkaloid ; Pyrrole derivatives ; Phenols ; Imide ; Bromine Organic compounds ;

Mots-clés français / French Keywords

Isolement ; Structure moléculaire ; Spectre RMN ; Alcaloïde ; Pyrrole dérivé ; Phénols ; Imide ; Hydrogène 1 ; Carbone 13 ; Polycitrine A ; Polycitrine B ; Polycitone A ; Polycitone A(penta-O-méthyl) ; Polycitor ; Brome Composé organique ;

Mots-clés espagnols / Spanish Keywords

Aislamiento ; Estructura molecular ; Espectro de RMN ; Alcaloide ; Pirrol derivado ; Fenoles ; Imida ; Bromo Compuesto orgánico ;

Localisation / Location

INIST-CNRS, Cote INIST : 602, 35400002563238.0150