Titre du document / Document title

Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy

Auteur(s) / Author(s)

WAAGSTEIN F. ⁽¹⁾ ; BRISTOW M. R. ; SWEDBERG K. ; CAMERINI F. ; FOWLER M. B. ; SILVER M. A. ; GILBERT E. M. ; JOHNSON M. R. ; GOSS F. G. ; HJALMARSON Å. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Univ. Göteborg, Sahlgren's hosp., div. cardiology, SUEDE

Résumé / Abstract

Several small studies have suggested beneficial effects of long-term β-blocker treatment in idiopathic dilated cardiomyopathy. Our large multicentre study aimed to find out whether metoprolol improves overall survival and morbidity in this disorder, 383 subjects with heart failure from idiopathic dilated cardiomyopathy (ejection fraction <0.40) were randomly assigned placebo or metoprolol. 94% were in New York Heart Association functional classes II and IIIl, and 80% were receiving background treatment. A test dose of metoprolol (5 mg twice daily) was given for 2-7 days; those tolerating this dose (96%) entered randomisation. Study medication was increased slowly from 10 mg to 100-150 mg daily

Revue / Journal Title

Lancet   ISSN 0140-6736   CODEN LANCAO 

Source / Source

1993, vol. 342, n^o8885, pp. 1441-1446 (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lancet, London, ROYAUME-UNI  (1823) (Revue)

Mots-clés anglais / English Keywords

Heart disease ; Treatment ; Human ; Left ventricle performance ; Hemodynamics ; Chemotherapy ; Constrictive hypertrophic cardiomyopathy ; Beta blocking agent ; Cardiovascular disease ;

Mots-clés français / French Keywords

Cardiopathie ; Traitement ; Homme ; Fonction ventriculaire gauche ; Hémodynamique ; Chimiothérapie ; Cardiomyopathie hypertrophique adiastolique ; Bloquant β-adrénergique ; Métoprolol ; Appareil circulatoire pathologie ;

Mots-clés espagnols / Spanish Keywords

Cardiopatía ; Tratamiento ; Hombre ; Función ventricular izquierda ; Hemodinámica ; Quimioterapia ; Cardiomiopatía hipertrófica adiastólica ; Bloqueador β-adrenérgico ; Aparato circulatorio patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 5004, 35400002449107.0060