Titre du document / Document title

Dose-dependent antagonism and potentiation of nitrous oxide antinociception by naloxone in mice

Auteur(s) / Author(s)

QUOCK R. M. ; CURTIS B. A. ; REYNOLDS B. J. ; MUELLER J. L. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Univ. Illinois coll. medicine Rockford, dep. biomedical sci., Rockford IL 61107-1897, ETATS-UNIS

Résumé / Abstract

Administration of the anesthetic gas nitrous oxide (N₂O) evoked a concentration-dependent antinociceptive effect in mice as assessed by the abdominal constriction test. Depending on the dose and route of pretreatment with the opioid receptor blocker naloxone, the N₂O drug effect was either antagonized or potentiated. After s.c. pretreatment with milligram per kilogram doses of naloxone, dose-related antagonism occurred; picogram per kilogram doses potentiated N₂O-induced antinociception. The i.c.v. pretreatment with microgram quantities of naloxone also antagonized N₂O antinociception in a dose-related fashion; i.c.v. pretreatment with femtogram doses was without effect

Revue / Journal Title

The Journal of pharmacology and experimental therapeutics   ISSN 0022-3565   CODEN JPETAB 

Source / Source

1993, vol. 267, n^o1, pp. 117-122 (1 p.)

Langue / Language

Anglais

Editeur / Publisher

American Society for Pharmacology and Experimental Therapeutics, Bethesda, MD, ETATS-UNIS  (1909) (Revue)

Mots-clés anglais / English Keywords

Narcotic antagonist ; Nitrogen protoxide ; General anesthetic ; Volatile compound ; Dose activity relation ; Antagonism ; Animal ; Mouse ; Potentiation ; Analgesia ; Nociception ; Pain ; Mechanism of action ; Rodentia ; Mammalia ; Vertebrata ;

Mots-clés français / French Keywords

Naloxone ; Antagoniste analgésique narcotique ; Azote protoxyde ; Anesthésique général ; Composé volatil ; Relation dose réponse ; Antagonisme ; Animal ; Souris ; Potentialisation ; Analgésie ; Nociception ; Douleur ; Mécanisme action ; Rodentia ; Mammalia ; Vertebrata ;

Mots-clés espagnols / Spanish Keywords

Antagonista narcótico ; Nitrógeno protóxido ; Anestésico general ; Compuesto volátil ; Relación dosis respuesta ; Antagonismo ; Animal ; Ratón ; Potencialización ; Analgesia ; Nocicepción ; Dolor ; Mecanismo acción ; Rodentia ; Mammalia ; Vertebrata ;

Localisation / Location

INIST-CNRS, Cote INIST : 548, 35400002634443.0160