Titre du document / Document title

Fiber type composition and enzyme activities of muscles in two models of obese rats

Auteur(s) / Author(s)

PUJOL A. ⁽¹⁾ ; LEFAUCHEUR L. ⁽²⁾ ; ECOLAN P. ⁽²⁾ ; PICON L. ⁽¹⁾ ; PENICAUD L. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ CNRS Univ. Paris VII, lab. physiopathologie nutrition, 75251 Paris, FRANCE
⁽²⁾ INRA Saint Gilles, stn. rech. porcines, 35590 L'Hermitage, FRANCE

Résumé / Abstract

1. In oxidative (soleus) and glycolytic (extensor digitorum longus) muscles of obese Zucker rats, a significant decrease in the percentage of relative area occupied by glycolytic fibers was observed. 2. The activity of citrate synthase and β-hydroxy-acyl-CoA-dehydrogenase was significantly higher in muscles of obese than of lean Zucker rats. 3. In rats, 6 weeks after lesion of the ventromedial hypothalamus, no changes were observed. 4. This indicates that neither the proportion of oxidative fibers, nor the oxidative capacities are decreased in skeletal muscles of obese rats suggesting that insulin resistance cannot be ascribed to a higher glycolytic-oxidative fiber ratio

Revue / Journal Title

Comparative biochemistry and physiology. B. Comparative biochemistry   ISSN 0305-0491   CODEN CBPBB8 

Source / Source

1993, vol. 106, n^o2, pp. 269-272 (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1971-1993) (Revue)

Mots-clés anglais / English Keywords

Rat ; Metabolism ; Enzymatic activity ; Soleus muscle ; Extensor digitorum muscle ; Obesity ; Muscular fiber ; Rodentia ; Mammalia ; Vertebrata ; Striated muscle ;

Mots-clés français / French Keywords

Rat ; Métabolisme ; Activité enzymatique ; Muscle soléaire ; Muscle extenseur doigt ; Obésité ; Fibre musculaire ; Rodentia ; Mammalia ; Vertebrata ; Muscle strié ;

Mots-clés espagnols / Spanish Keywords

Rata ; Metabolismo ; Actividad enzimática ; Músculo sóleo ; Músculo extensor dedo ; Obesidad ; Fibra muscular ; Rodentia ; Mammalia ; Vertebrata ; Músculo estriado ;

Localisation / Location

INIST-CNRS, Cote INIST : 1190 B, 35400003573491.0070