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Titre du document / Document title

Autocidal biological control : a general strategy for insect control based on genetic transformation with a highly conserved gene

Auteur(s) / Author(s)

FRYXELL K. J. (1) ; MILLER T. A. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Univ. California, dep. biology, Riverside CA 92521, ETATS-UNIS

Résumé / Abstract

Notch60g11 is a sex-linked mutation in Drosophila melanogaster (Meigen) (Diptera: Drosophilidae) that causes dominant, cold-sensitive lethality in heterozygous embryos. A population of normal D. melanogaster was driven to extinction by adding an equal number of homozygous Notch60g11 mutants to each of 3 successive generations at 18°C. Notch60g11 homozygotes raised at 26°C showed normal viability and mating success, even in competition with a wild-type insect population, presumably because of the developmental stage-specificity of the Notch60g11 mutation. The Notch60g11 mutants used in this test were intended to model the transgenic insects that may be produced in other species by genetic transformation with a genetically engineered mutant gene similar to Notch60g11. Therefore, our mutant strain carried not only 2 copies of the Notch60g11 mutant gene on one pair of chromosomes, but also 2 copies of the normal Notch gene on another pair of chromosomes. Because Notch60g11 is a frameshift mutation in a gene that is highly conserved in arthropods and vertebrates, this autocidal biological control strategy could be used in any insect species that reproduces sexually and lives in a temperate climate.

Revue / Journal Title

Journal of economic entomology    ISSN  0022-0493   CODEN JEENAI 

Source / Source

1995, vol. 88, no5, pp. 1221-1232 (3 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

Entomological Society of America, Lanham, MD, ETATS-UNIS  (1908) (Revue)

Mots-clés anglais / English Keywords

Biological control

;

Autocidal control

;

Genetic transformation

;

Mutation

;

Fertility

;

Mortality

;

Population extinction

;

Drosophila melanogaster

;

Drosophilidae

;

Diptera

;

Insecta

;

Arthropoda

;

Invertebrata

;

Mots-clés français / French Keywords

Lutte biologique

;

Lutte autocide

;

Transformation génétique

;

Mutation

;

Fertilité

;

Mortalité

;

Extinction population

;

Drosophila melanogaster

;

Drosophilidae

;

Diptera

;

Insecta

;

Arthropoda

;

Invertebrata

;

Mots-clés espagnols / Spanish Keywords

Lucha biológica

;

Lucha autocida

;

Transformación genética

;

Mutación

;

Fertilidad

;

Mortalidad

;

Extinción población

;

Drosophila melanogaster

;

Drosophilidae

;

Diptera

;

Insecta

;

Arthropoda

;

Invertebrata

;

Localisation / Location

INIST-CNRS, Cote INIST : 6318, 35400005021978.0230

Nº notice refdoc (ud4) : 3696050



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