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Titre du document / Document title

Aqueous degradation of isoflavonoids in an extract of Millettia thonningii (Leguminosae) which is larvicidal towards schistosomes

Auteur(s) / Author(s)

PERRETT S. ; WHITFIELD P. J. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

King's coll. London, div. life sci., infection immunity res. group, London W8 7AH, ROYAUME-UNI

Résumé / Abstract

A chloroform extract of the seeds of the West African legume Millettia thonningii has been shown to kill the snails which transmit the schistosomiasis and also the larvae of the parasite itself. This study examines the bioactivity of the chloroform extract of M. thonningii in aqueous non-sterile conditions. Suspensions of the extract in water maintained larvicidal activity for long periods. HPLC analysis showed that over a period of 4 weeks in aqueous suspension, degradation of two of the compounds present, the isoflavonoids alpinumisoflavone and 4'-methyl-alpinumisoflavone, occurred and bioactivity was eventually lost, indicating that these compounds are probably responsible for the bioactivity. These isoflavonoids are thought to act via inhibition of electron transport.

Revue / Journal Title

PTR. Phytotherapy research    ISSN  0951-418X 

Source / Source

1995, vol. 9, no6, pp. 401-404 (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Chichester, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Medicinal plant

;

Plant origin

;

Extract

;

Isoflavone derivatives

;

Parasiticid

;

Schistosomiasis

;

Schistosoma mansoni

;

Molluscicide

;

Cercaria

;

Larva

;

In vitro

;

Seeds

;

Pharmacognosy

;

Folk medicine

;

West Africa

;

Trematod disease

;

Helminthiasis

;

Parasitosis

;

Infection

;

Trematoda

;

Plathelmintha

;

Helmintha

;

Invertebrata

;

Leguminosae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Africa

;

Mots-clés français / French Keywords

Plante médicinale

;

Origine végétale

;

Extrait

;

Isoflavone dérivé

;

Antiparasitaire

;

Schistosomiase

;

Schistosoma mansoni

;

Molluscicide

;

Cercaire

;

Larve

;

In vitro

;

Graine

;

Pharmacognosie

;

Médecine traditionnelle

;

Afrique Ouest

;

Isoflavonoïde

;

Alpinumisoflavone

;

Robustique acide

;

Millettia thonningii

;

Trématodose

;

Helminthiase

;

Parasitose

;

Infection

;

Trematoda

;

Plathelmintha

;

Helmintha

;

Invertebrata

;

Leguminosae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Afrique

;

Mots-clés espagnols / Spanish Keywords

Planta medicinal

;

Origen vegetal

;

Extracto

;

Antiparasitario

;

Esquistosomiasis

;

Schistosoma mansoni

;

Molusquicida

;

Cercaria

;

Larva

;

In vitro

;

Semillas

;

Farmacognosia

;

Medicina tradicional

;

Africa occidental

;

Trematodosis

;

Helmintiasis

;

Parasitosis

;

Infección

;

Trematoda

;

Plathelmintha

;

Helmintha

;

Invertebrata

;

Leguminosae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Africa

;

Localisation / Location

INIST-CNRS, Cote INIST : 21695, 35400005464608.0020

Nº notice refdoc (ud4) : 3653092



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