Titre du document / Document title

Insulin resistance in adipocytes of obese women : effects of body fat distribution and race

Auteur(s) / Author(s)

DOWLING H. J. ; FRIED S. K. ; PI-SUNYER F. X. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Columbia univ. coll. physicians surgeons, St. Luke's/Roosevelt hosp. cent., dep. medicine, New York NY, ETATS-UNIS

Résumé / Abstract

Upper-body obesity (UBO) in white women is associated with increased fatty acid turnover and resistance to the effects of insulin on systemic glucose metabolism. The present study determined whether the abilities of insulin to stimulate glucose transport and suppress lipolysis are impaired in adipocytes from white UBO (W-UBO) women. Because the clinical risks associated with UBO are attenuated in black women, the effects of race on adipocyte insulin sensitivity were assessed. Forty-two healthy, equally obese women were selected for study on the basis of race (black or white) and body fat distribution (UBO or lower-body obesity [LBO]). In white women, both abdominal and gluteal fat cells from the UBO versus LBO group were less responsive to the stimulatory effects of insulin on glucose uptake and less sensitive to the antilipolytic effects of insulin and the adenosine analog, phenylisopropyladenosine (PIA). In contrast, in black women, fat cells from UBO and LBO groups were equally sensitive to the stimulatory effects of insulin on glucose transport and the suppressive effects of insulin and PIA on lipolysis. These in vitro data correlate well with previous clinical findings that UBO in white women but not in black women is associated with insulin resistance and dyslipidemia. Thus, resistance to the antilipolytic effects of insulin and adenosine at the level of adipose tissue may increase systemic lipolysis and play a role in the development or maintenance of peripheral insulin resistance associated with UBO in white women, but not in black women.

Revue / Journal Title

Metabolism, clinical and experimental   ISSN 0026-0495 

Source / Source

1995, vol. 44, n^o8, pp. 987-995 (43 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1952) (Revue)

Mots-clés anglais / English Keywords

Obesity ; Human ; Female ; Insulin ; Target tissue resistance ; Adipocyte ; Race ; Distribution ; Adipose tissue ; Nutritional status ; Nutrition disorder ;

Mots-clés français / French Keywords

Obésité ; Homme ; Femelle ; Insuline ; Résistance tissu cible ; Adipocyte ; Race ; Distribution ; Tissu adipeux ; Etat nutritionnel ; Trouble nutrition ;

Mots-clés espagnols / Spanish Keywords

Obesidad ; Hombre ; Hembra ; Insulina ; Resistencia tejido blanco ; Adipocito ; Raza ; Distribución ; Tejido adiposo ; Estado nutricional ; Trastorno nutricíon ;

Localisation / Location

INIST-CNRS, Cote INIST : 6965, 35400005437067.0050