Titre du document / Document title

Comparison of effects of N-3 to N-6 fatty acids on serum level of lipoprotein(a) in patients with coronary artery disease

Auteur(s) / Author(s)

HERRMANN W. ; BIERMANN J. ; KOSTNER G. M. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Univ. Regensburg, Inst. Klin. Chemie und Laboratoriumsmedizin, 93042 Regensburg, ALLEMAGNE

Résumé / Abstract

The influence of dietary supplementation with n-3 versus n-6 fatty acids on plasma lipoprotein(a) (Lp[a]) levels was studied. Thirty-five male hospitalized patients with coronary artery disease were treated for 4 weeks with 12 g/day of fish oil (8.5 g of n-3 fatty acids) in combination with a 5,000 kilojoule, 30% fat diet and moderate exercise. Eighteen control patients given the same dietary and training program were treated with 12 g/day of rapeseed oil. Plasma Lp(a), in addition to several lipids and lipoproteins, blood clotting factors, and platelet reactivity, were measured before and at the end of therapy. Results can be summarized as follows: total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B levels decreased significantly in both the rapeseed oil (-14.4%, -20.3%, -15.2%, respectively) and fish oil (-12.2%, -16.0%, and -14.2%, respectively) groups. Triglycerides decreased (-20.3%) and high-density lipoprotein cholesterol increased (+8.3%) significantly only in patients treated with fish oil. Plasma Lp(a) levels were reduced by 14% in the fish oil group, but unaffected in the rapeseed oil group. Patients treated with fish oil could be categorized into 2 subgroups : responders, with a reduction in Lp(a) by 24% and nonresponders, with a small nonsignificant increase in serum Lp(a). Responders and nonresponders exhibited a marked reduction in cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and triglycerides, and an increase in high-density lipoprotein₃ cholesterol. There was a large reduction in tissue plasminogen activator in the fish oil group, which correlated significantly with reduction in Lp(a). Platelet number and aggregation behavior were not significantly changed in either group. No physiologic differences were seen between responders and nonresponders.

Revue / Journal Title

The American journal of cardiology   ISSN 0002-9149   CODEN AJCDAG 

Source / Source

1995, vol. 76, n^o7, pp. 459-462 (28 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1958) (Revue)

Mots-clés anglais / English Keywords

Coronary heart disease ; Supplemented diet ; Diet therapy ; High dose ; Physical exercise ; Comparative study ; Polyunsaturated fatty acid ; Serum ; Human ; Cardiovascular disease ;

Mots-clés français / French Keywords

Cardiopathie coronaire ; Régime alimentaire enrichi ; Traitement diététique ; Dose forte ; Exercice physique ; Etude comparative ; Acide gras polyinsaturé ; Sérum ; Homme ; Lipoprotéine a ; Appareil circulatoire pathologie ;

Mots-clés espagnols / Spanish Keywords

Cardiopatía coronaria ; Régimen alimenticio enriquecido ; Tratamiento dietético ; Dosis fuerte ; Ejercicio físico ; Estudio comparativo ; Acido graso poliinsaturado ; Suero ; Hombre ; Aparato circulatorio patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 8674, 35400005414934.0060