Titre du document / Document title

Circulating oxytocin and vasopressin is influenced by ovarian steroid replacement in women

Auteur(s) / Author(s)

BOSSMAR T. ⁽¹⁾ ; FORSLING M. ; AKERLUND M. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Univ. hosp., dep. obstetrics gynecology, 221 85 Lund, SUEDE

Résumé / Abstract

Background : The posterior pituitary hormones appear to be involved in the etiology of primary dysmenorrhaea, but mechanisms regulating their release, particularly the influence of ovarian steroids, are not fully understood. Methods. The effect of 17β-estradiol and medroxyprogesterone alone and in combination on oxytocin and vasopressin levels was therefore studied in 10 postmenopausal women. Results. Transdermal treatment with estradiol alone by means of patches in a dose of 100 μg/24 h for five days resulted in an elevation of the mean plasma concentration of this hormone from undetectable to 262 pmol/l and increase in mean circulating levels of vasopressin from 0.82 to 1.22 pmol/l and of oxytocin from 2.50 to 3.98 pmol/l. Oral administration of medroxy-progesterone in a dose of 10 mg per day for 5 days, which resulted in a mean plasma level of 4.3 nmol/l, suppressed vasopressin concentrations to 0.60 pmol/l. When given after five days of treatment with estradiol, medroxyprogesterone also antagonized the stimulatory effect of the estrogen on vasopressin secretion. Medroxyprogesterone alone increased the plasma oxytocin concentration to 3.26 pmol/l, but the progestogen did not significantly influence the stimulatory effect of estradiol on oxytocin secretion. Conclusions. It is concluded that posterior pituitary hormone secretion is influenced by estradiol and progestogens, and that this may be a mechanism for the involvement of ovarian hormones in the etiology of primary dysmenorrhaea.

Revue / Journal Title

Acta obstetricia et gynecologica Scandinavica   ISSN 0001-6349   CODEN AOGSAE 

Source / Source

1995, vol. 74, n^o7, pp. 544-548 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Taylor & Francis, Colchester, ROYAUME-UNI  (1925) (Revue)

Mots-clés anglais / English Keywords

Vasopressin ; Blood plasma ; Concentration ; Assay ; Palliative treatment ; Chemotherapy ; Human ; Female ; Dysmenorrhea ; Primary ; Estradiol ; Medroxyprogesterone ; Postmenopause ; Estrogen ; Progestagen ; Ovarian hormone ; Sex steroid hormone ; Oxytocic ; Female genital diseases ; Neuropeptide ; Neurohypophyseal hormone ; Peptide hormone ; Menstruation disorders ;

Mots-clés français / French Keywords

Oxytocine ; Vasopressine ; Plasma sanguin ; Concentration ; Dosage ; Traitement palliatif ; Chimiothérapie ; Homme ; Femelle ; Dysménorrhée ; Primaire ; Oestradiol ; Médroxyprogestérone ; Postménopause ; Oestrogène ; Progestatif ; Hormone ovarienne ; Hormone stéroïde sexuelle ; Ocytocique ; Appareil génital femelle pathologie ; Neuropeptide ; Hormone neurohypophysaire ; Hormone peptide ; Cycle menstruel pathologie ;

Mots-clés espagnols / Spanish Keywords

Plasma sanguíneo ; Concentración ; Dosificación ; Tratamiento paliativo ; Quimioterapia ; Hombre ; Hembra ; Dismenorrea ; Primario ; Estradiol ; Medroxiprogesterona ; Postmenopausia ; Estrógeno ; Progestágeno ; Hormona ovárica ; Hormona esteroide sexual ; Ocitócico ; Aparato genital hembra patología ; Neuropéptido ; Hormona neurohipofisaria ; Hormona péptido ; Ciclo menstrual patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 964 A, 35400005187027.0100