Titre du document / Document title

progressive outer retinal necrosis(PORN) in AIDS patients: a different appearance of varicella-Zoster retinitis

Auteur(s) / Author(s)

PAVESIO C. E. ; MITCHELL S. M. ; BARTON K. ; SCHWARTZ S. D. ; TOWLER H. M. A. ; LIGHTMAN S. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Moorfields eye hosp., uveitis acquired immunodeficiency syndrome clin., London, ROYAUME-UNI

Résumé / Abstract

Retinal infections caused by the varicella-zoster virus (VZV) have been reported in immunocompetent and immunocompromised individuals. Two cases of a VZV-related retinitis are described with the characteristic features of the recently described progressive outer retinal necrosis (PORN) syndrome. Both patients suffered from the acquired immunodeficiency syndrome (AIDS) with greatly reduced peripheral blood CD4⁺ T lymphocyte counts, and presented with macular retinitis without vitritis. The disease was bilateral in one case and unilateral in the other. The clinical course was rapidly progressive with widespread retinal involvement and the development of rhegmatogenous retinal detachment with complete loss of vision in the affected eyes despite intensive intravenous antiviral therapy. VZV DNA was identified in vitreous biopsies, by molecular techniques based on the polymerase chain reaction (PCR), in both patients. At present, the use of very high-dose intravenous acyclovir may be the best therapeutic option in these patients for whom the visual prognosis is poor. Intravitreal antiviral drugs could also contribute to the management of these cases.

Revue / Journal Title

Eye   ISSN 0950-222X   CODEN EYEEEC 

Source / Source

1995, vol. 9 (3), pp. 271-276 (20 ref.)

Langue / Language

Anglais

Editeur / Publisher

Nature Publishing Group, Basingstoke, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

AIDS ; Retinitis ; Necrosis ; Chronic ; Varicella zoster virus ; Chemotherapy ; Treatment ; Antiviral ; Case study ; Human ; Acyclic nucleoside ; Purine nucleoside ; Viral disease ; Infection ; Alphaherpesvirinae ; Herpesviridae ; Virus ; Immunopathology ; Immune deficiency ; Eye disease ; Retinopathy ;

Mots-clés français / French Keywords

SIDA ; Rétinite ; Nécrose ; Chronique ; Virus varicelle ; Chimiothérapie ; Traitement ; Aciclovir ; Antiviral ; Etude cas ; Homme ; Nucléoside acyclique ; Purine nucléoside ; Virose ; Infection ; Alphaherpesvirinae ; Herpesviridae ; Virus ; Immunopathologie ; Immunodéficit ; Oeil pathologie ; Rétinopathie ;

Mots-clés espagnols / Spanish Keywords

SIDA ; Retinitis ; Necrosis ; Crónico ; Varicella zoster virus ; Quimioterapia ; Tratamiento ; Antiviral ; Estudio caso ; Hombre ; Nucleósido acíclico ; Purina nucleósido ; Virosis ; Infección ; Alphaherpesvirinae ; Herpesviridae ; Virus ; Inmunopatología ; Inmunodeficiencia ; Ojo patología ; Retinopatía ;

Localisation / Location

INIST-CNRS, Cote INIST : 21076, 35400005152658.0030